CD300LB
CMRF35-like molecule 7
Protein Summary
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]
- ENST00000392621
- ENSP00000376397
- ENSG00000178789
- CD300B
- CLM7
- CMRF35A2
- IREM3
- LMIR5
- TREM5
- CLM7
- CLM-7
- IREM3
- TREM5
- CD300b
- IREM-3
- TREM-5
- CMRF35-A2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.64 | ||
cell type or tissue | 0.58 | ||
protein domain | 0.58 | ||
gene perturbation | 0.5 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.04 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 99 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.04 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 99 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (103)
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | DAP12 interactions | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
DAP12 interactions | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 1 | 1 | 70.5 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 14 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 70.5 | |||||
monocyte percentage of leukocytes | 1 | 14 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD300 molecule like family member b | VGNC:9175 | 468319 | |||||
Mouse | MGI:2685099 | 217304 | ||||||
Rat | RGD:1583718 | 501738 | ||||||
Dog | CMRF35-like molecule 7 | 100686711 | ||||||
Cow | CD300 molecule-like family member b | 789755 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD300 molecule like family member b | |||||
Mouse | ||||||
Rat | ||||||
Dog | CMRF35-like molecule 7 | |||||
Cow | CD300 molecule-like family member b | |||||
Publication Statistics
PubMed Score 12.04
PubMed score by year
PubTator Score 4.66
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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