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Tbio
CD300C
CMRF35-like molecule 6

Protein Summary
Description
The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330793
  • ENSP00000329507
  • ENSG00000167850

Symbol
  • CMRF35
  • CMRF35A
  • CMRF35A1
  • IGSF16
  • LIR
  • CLM-6
  • CMRF35
  • IGSF16
  • CMRF-35
  • CMRF35A
  • CMRF-35A
  • CMRF35A1
  • CMRF35-A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
disease perturbation
0.62
protein domain
0.58
transcription factor perturbation
0.54
gene perturbation
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.3   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.3   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
FAM210A
Tdark
Novelty:  0.2598101
p_int:  0.917266937
p_ni:  0.082733063
Score:  0.692
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.899054351
p_ni:  0.100945649
Score:  0.219
Data Source:  BioPlex,STRINGDB
LILRB1
Tbio
Novelty:  0.00463824
Score:  0.833
Data Source:  STRINGDB
LILRA1
Tbio
Novelty:  0.17371827
Score:  0.824
Data Source:  STRINGDB
LILRA2
Tbio
Novelty:  0.05598199
Score:  0.824
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.801
Data Source:  STRINGDB
NBR1
Tbio
Novelty:  0.00893066
Score:  0.796
Data Source:  STRINGDB
MAP1LC3B
Tbio
Novelty:  0.00101276
Score:  0.777
Data Source:  STRINGDB
LILRB4
Tbio
Novelty:  0.01443658
Score:  0.766
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.76
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
3
4
87.1
alkaline phosphatase measurement
1
1
1
60.8
monocyte percentage of leukocytes
1
1
1
11.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
87.1
alkaline phosphatase measurement
1
60.8
monocyte percentage of leukocytes
1
11.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD300c molecule
VGNC:9174
468320
Mouse
MGI:2153249
140497
Horse
CMRF35-like molecule 6
100630791
Cow
CMRF35-like molecule 6
526163
Pig
CD300c molecule
100514248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD300c molecule
Mouse
Horse
CMRF35-like molecule 6
Cow
CMRF35-like molecule 6
Pig
CD300c molecule
Publication Statistics
PubMed Score 426.30
PubMed score by year
PubTator Score 68.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title