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Tclin
CD274
Programmed cell death 1 ligand 1

Protein Summary
Description
Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is impo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381573
  • ENSP00000370985
  • ENSG00000120217
  • ENST00000381577
  • ENSP00000370989

Symbol
  • B7H1
  • PDCD1L1
  • PDCD1LG1
  • PDL1
  • B7-H
  • B7H1
  • PDL1
  • PD-L1
  • PDCD1L1
  • PDCD1LG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.99
histone modification site profile
0.78
protein domain
0.73
biological process
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13269.92   (req: < 5)
Gene RIFs: 963   (req: <= 3)
Antibodies: 1403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13269.92   (req: >= 5)
Gene RIFs: 963   (req: > 3)
Antibodies: 1403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3