Tclin CD274 Programmed cell death 1 ligand 1

Protein Summary

Description

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q9NZQ7
• B2RBA2
• B4DU27
• Q14CJ2
• Q2V8D5
• Q66RK1
• Q6WEX4
• Q9NUZ5
• PD-L1

Gene Name

• CD274

Ensembl ID

• ENST00000381573
• ENSP00000370985
• ENSG00000120217
• ENST00000381577
• ENSP00000370989

Symbol

• B7H1
• PDCD1L1
• PDCD1LG1
• PDL1
• B7-H
• B7H1
• PDL1
• PD-L1
• PDCD1L1
• PDCD1LG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological term	0.99
histone modification site profile	0.78
protein domain	0.73
biological process	0.72

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Programmed Cell Death 1 Ligand 1

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Programmed Cell Death 1 Ligand 1

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Programmed Cell Death 1 Ligand 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Programmed Cell Death 1 Ligand 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13269.92   (req: < 5)

Gene RIFs: 2486   (req: <= 3)

Antibodies: 1403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13269.92   (req: >= 5)

Gene RIFs: 2486   (req: > 3)

Antibodies: 1403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3