Protein Summary
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
- ENST00000266557
- ENSP00000266557
- ENSG00000139193
- TNFRSF7
- T14
- S152
- Tp55
- TNFRSF7
- S152. LPFS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.92 | ||
biological term | 0.75 | ||
cell type or tissue | 0.7 | ||
gene perturbation | 0.7 | ||
tissue sample | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1134.23 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 1851 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1134.23 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 1851 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (243)
SLC25A51
Family: Transporter
Novelty: 0.21568087
p_int: 0.999988721
p_ni: 0.000011277
p_wrong: 2e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
C1GALT1
Family: Enzyme
Novelty: 0.01191596
p_int: 0.999988104
p_ni: 0.000011896
Score: 0.222
Data Source: BioPlex,STRINGDB
CD70
Novelty: 0.00420393
p_int: 0.999982532
p_ni: 0.00001164
p_wrong: 0.000005827
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
TCAF2
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999946877
p_ni: 0.00005307
p_wrong: 5.4e-8
Data Source: BioPlex
SEMG1
Novelty: 0.0161449
p_int: 0.996792559
p_ni: 0.003207402
p_wrong: 3.9e-8
Data Source: BioPlex
ATP2B3
Family: Transporter
Novelty: 0.00901493
p_int: 0.99311844
p_ni: 0.006881548
p_wrong: 1.2e-8
Data Source: BioPlex
SLC19A2
Family: Transporter
Novelty: 0.00761796
p_int: 0.990357235
p_ni: 0.009642765
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (4)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 3 | 4 | 96 | |||||
platelet crit | 2 | 4 | 4 | 93.3 | |||||
monocyte count | 2 | 2 | 2 | 88.7 | |||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 87.6 | |||||
neutrophil percentage of leukocytes | 2 | 2 | 2 | 85.2 | |||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 4 | 96 | |||||
platelet crit | 4 | 93.3 | |||||
monocyte count | 2 | 88.7 | |||||
monocyte percentage of leukocytes | 2 | 87.6 | |||||
neutrophil percentage of leukocytes | 2 | 85.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD27 molecule | VGNC:5329 | 451780 | |||||
Macaque | CD27 molecule | 712693 | ||||||
Mouse | MGI:88326 | 21940 | ||||||
Rat | RGD:1560499 | 500318 | ||||||
Dog | CD27 molecule | VGNC:38941 | 611674 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD27 molecule | |||||
Macaque | CD27 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD27 molecule | |||||
Publication Statistics
PubMed Score 1134.23
PubMed score by year
PubTator Score 695.25
PubTator score by year
Related Publications
Text Mined References (103)
GeneRif Annotations (75)
Items per page:
0 of 0
PMID | Year | Title |
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