Tbio CD27 CD27 antigen

Protein Summary

Description

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P26842
• B2RDZ0

Gene Name

• CD27

Ensembl ID

• ENST00000266557
• ENSP00000266557
• ENSG00000139193

Symbol

• TNFRSF7
• T14
• S152
• Tp55
• TNFRSF7
• S152. LPFS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
biological term	0.75
cell type or tissue	0.7
gene perturbation	0.7
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1134.23   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 1851   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1134.23   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 1851   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (243)

Explore Interacting Targets

1 – 10 of 243

• See Interactions on String-DB

SLC25A51

Tbio

Family:  Transporter

Novelty:  0.21568087

p_int:  0.999988721

p_ni:  0.000011277

p_wrong:  2e-9

Score:  0.205

Data Source:  BioPlex,STRINGDB

C1GALT1

Tbio

Family:  Enzyme

Novelty:  0.01191596

p_int:  0.999988104

p_ni:  0.000011896

Score:  0.222

Data Source:  BioPlex,STRINGDB

CD70

Tbio

Novelty:  0.00420393

p_int:  0.999982532

p_ni:  0.00001164

p_wrong:  0.000005827

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

TCAF2

Tbio

Family:  Enzyme

Novelty:  0.37070492

p_int:  0.999946877

p_ni:  0.00005307

p_wrong:  5.4e-8

Data Source:  BioPlex

TMEM67

Tbio

Novelty:  0.02573267

p_int:  0.999944553

p_ni:  0.000055447

Data Source:  BioPlex

SEMG2

Tbio

Novelty:  0.06325799

p_int:  0.99717293

p_ni:  0.00282707

Data Source:  BioPlex

SEMG1

Tbio

Novelty:  0.0161449

p_int:  0.996792559

p_ni:  0.003207402

p_wrong:  3.9e-8

Data Source:  BioPlex

ATP2B3

Tbio

Family:  Transporter

Novelty:  0.00901493

p_int:  0.99311844

p_ni:  0.006881548

p_wrong:  1.2e-8

Data Source:  BioPlex

GOLGA5

Tbio

Novelty:  0.04940885

p_int:  0.991098275

p_ni:  0.008901725

Data Source:  BioPlex

SLC19A2

Tbio

Family:  Transporter

Novelty:  0.00761796

p_int:  0.990357235

p_ni:  0.009642765

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	TNFR2 non-canonical NF-kB pathway	101 targets	R-HSA-5668541
Reactome	TNFs bind their physiological receptors	28 targets	R-HSA-5669034

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
TNFR2 non-canonical NF-kB pathway	101 targets	R-HSA-5668541
TNFs bind their physiological receptors	28 targets	R-HSA-5669034

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (2)

Components (4)

Processes (11)

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1 – 2 of 2

GO Term	Evidence	Assigned by
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane signaling receptor activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (26)

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5

1 – 5 of 26

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	3	4		96
platelet crit	EFO_0007985	2	4	4		93.3
monocyte count	EFO_0005091	2	2	2		88.7
monocyte percentage of leukocytes	EFO_0007989	2	1	2		87.6
neutrophil percentage of leukocytes	EFO_0007990	2	2	2		85.2

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	4		96
platelet crit	EFO_0007985	4		93.3
monocyte count	EFO_0005091	2		88.7
monocyte percentage of leukocytes	EFO_0007989	2		87.6
neutrophil percentage of leukocytes	EFO_0007990	2		85.2

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Apoptosis
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
basophil count
body weights and measures
celiac disease
cortical surface area measurement
Crohn's disease
eosinophil count
eosinophil percentage of leukocytes
granulocyte percentage of myeloid white cells
leukocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD27 molecule	VGNC:5329	451780
Macaque	CD27 molecule		712693
Mouse	CD27 antigen	MGI:88326	21940
Rat	CD27 molecule	RGD:1560499	500318
Dog	CD27 molecule	VGNC:38941	611674

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD27 molecule
Macaque	CD27 molecule
Mouse	CD27 antigen
Rat	CD27 molecule
Dog	CD27 molecule

Publication Statistics

PubMed Score 1134.23

PubMed score by year

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PubTator Score 695.25

PubTator score by year

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Related Publications

Text Mined References (103)

GeneRif Annotations (75)

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PMID	Year	Title