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Tbio
CD244
Natural killer cell receptor 2B4

Protein Summary
Description
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322302
  • ENSP00000313619
  • ENSG00000122223
  • ENST00000368033
  • ENSP00000357012
  • ENST00000368034
  • ENSP00000357013
  • ENST00000492063
  • ENSP00000432636

Symbol
  • 2B4
  • 2B4
  • NAIL
  • Nmrk
  • NKR2B4
  • SLAMF4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological term
0.68
gene perturbation
0.6
kinase perturbation
0.54
transcription factor
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.92   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 667   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.92   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.999997983
p_ni:  0.000002006
p_wrong:  1.1e-8
Score:  0.635
Data Source:  BioPlex,STRINGDB
POMT2
Tbio
Family:  Enzyme
Novelty:  0.0251595
p_int:  0.999986366
p_ni:  0.000013634
Data Source:  BioPlex
POMT1
Tbio
Family:  Enzyme
Novelty:  0.01971429
p_int:  0.99994816
p_ni:  0.00005184
Data Source:  BioPlex
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
p_int:  0.999527546
p_ni:  0.000472454
Score:  0.158
Data Source:  BioPlex,STRINGDB
MYADM
Tbio
Novelty:  0.11475375
p_int:  0.996323529
p_ni:  0.002661402
p_wrong:  0.001015069
Data Source:  BioPlex
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.989851933
p_ni:  0.010148066
Data Source:  BioPlex
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
p_int:  0.974646484
p_ni:  0.025353516
Score:  0.183
Data Source:  BioPlex,STRINGDB
MTX2
Tbio
Novelty:  0.02047483
p_int:  0.958717936
p_ni:  0.041282064
Score:  0.823
Data Source:  BioPlex,STRINGDB
RNF213
Tbio
Family:  Enzyme
Novelty:  0.00588778
p_int:  0.953443877
p_ni:  0.046556035
p_wrong:  8.8e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
IMMT
Tbio
Novelty:  0.00260309
p_int:  0.952803723
p_ni:  0.047196277
Score:  0.819
Data Source:  BioPlex,STRINGDB
Pathways (3)
Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
92.5
lymphocyte percentage of leukocytes
2
3
3
85.8
2
2
0
1.1
68.5
neutrophil percentage of leukocytes
1
1
1
40.7
1
1
0
1.1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
92.5
lymphocyte percentage of leukocytes
3
85.8
0
1.1
68.5
neutrophil percentage of leukocytes
1
40.7
0
1.1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD244 molecule
VGNC:7358
457439
Macaque
CD244 molecule
719800
Mouse
MGI:109294
18106
Rat
RGD:68400
64025
Dog
CD244 molecule
VGNC:53117
488644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD244 molecule
Macaque
CD244 molecule
Mouse
Rat
Dog
CD244 molecule
Publication Statistics
PubMed Score 72.92
PubMed score by year
PubTator Score 236.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title