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Tbio
CD244
Natural killer cell receptor 2B4

Protein Summary
Description
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322302
  • ENSP00000313619
  • ENSG00000122223
  • ENST00000368033
  • ENSP00000357012
  • ENST00000368034
  • ENSP00000357013
  • ENST00000492063
  • ENSP00000432636

Symbol
  • 2B4
  • 2B4
  • NAIL
  • Nmrk
  • NKR2B4
  • SLAMF4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological term
0.68
gene perturbation
0.6
kinase perturbation
0.54
transcription factor
0.54


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.93   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 667   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.93   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0