Protein Summary
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
- ENST00000085219
- ENSP00000085219
- ENSG00000012124
- ENST00000341773
- ENSP00000339349
- ENST00000419549
- ENSP00000403822
- ENST00000536635
- ENSP00000442279
- ENST00000544992
- ENSP00000441237
- ENST00000594250
- ENSP00000469984
- SIGLEC2
- SIGLEC2
- SIGLEC-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
cellular component | 0.69 | ||
transcription factor | 0.62 | ||
tissue | 0.61 | ||
kinase perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1108.82 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 2035 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1108.82 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 2035 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (9)
Protein-Protein Interactions (168)
CPA4
Family: Enzyme
Novelty: 0.01439845
p_int: 0.939567217
p_ni: 0.060432783
Score: 0.226
Data Source: BioPlex,STRINGDB
S100A7
Novelty: 0.00434262
p_int: 0.846060521
p_ni: 0.153939479
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (6)
KEGG (3)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | CD22 mediated BCR regulation | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
CD22 mediated BCR regulation | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (6)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 5 | 7 | 92.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 73.5 | |||||
red blood cell density measurement | 1 | 1 | 1 | 53.7 | |||||
lymphocyte count | 1 | 1 | 1 | 47.7 | |||||
erythrocyte count | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 7 | 92.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 73.5 | |||||
red blood cell density measurement | 1 | 53.7 | |||||
lymphocyte count | 1 | 47.7 | |||||
erythrocyte count | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD22 molecule | VGNC:2369 | 450167 | |||||
Macaque | CD22 molecule | 106994739 | ||||||
Mouse | MGI:88322 | 12483 | ||||||
Rat | RGD:1311610 | 308501 | ||||||
Dog | CD22 molecule | VGNC:38939 | 476485 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD22 molecule | |||||
Macaque | CD22 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD22 molecule | |||||
Publication Statistics
PubMed Score 1108.82
PubMed score by year
PubTator Score 586.42
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (40)
Items per page:
0 of 0
PMID | Year | Title |
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