Tclin CD22 B-cell receptor CD22

Protein Summary

Description

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Uniprot Accession IDs

• P20273
• F5GYU4
• F5H7U3
• O95699
• O95701
• O95702
• O95703
• Q01665
• Q32M46
• Q92872
• Q92873
• Q9UQA6
• Q9UQA7
• Q9UQA8
• Q9UQA9
• Q9UQB0
• Q9Y2A6

Gene Name

• CD22

Ensembl ID

• ENST00000085219
• ENSP00000085219
• ENSG00000012124
• ENST00000341773
• ENSP00000339349
• ENST00000419549
• ENSP00000403822
• ENST00000536635
• ENSP00000442279
• ENST00000544992
• ENSP00000441237
• ENST00000594250
• ENSP00000469984

Symbol

• SIGLEC2
• SIGLEC2
• SIGLEC-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
cellular component	0.69
transcription factor	0.62
tissue	0.61
kinase perturbation	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1224.98   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 2035   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1224.98   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 2035   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2