Tbio CD200R1 Cell surface glycoprotein CD200 receptor 1

Protein Summary

Description

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TD46
• B3KWZ9
• E9PCM9
• Q52LJ7
• Q6IS95
• Q6UW94
• Q6WHB8
• Q8TD44
• Q8TD45
• Q8TD52

Gene Name

• CD200R1

Ensembl ID

• ENST00000308611
• ENSP00000311035
• ENSG00000163606
• ENST00000440122
• ENSP00000405733
• ENST00000471858
• ENSP00000418928
• ENST00000490004
• ENSP00000418801

Symbol

• CD200R
• CRTR2
• MOX2R
• OX2R
• OX2R
• MOX2R
• CD200R
• HCRTR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.81
protein domain	0.58
gene perturbation	0.56
tissue	0.56
microRNA	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.15   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 608   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.15   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0