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Tbio
CD200R1
Cell surface glycoprotein CD200 receptor 1

Protein Summary
Description
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308611
  • ENSP00000311035
  • ENSG00000163606
  • ENST00000440122
  • ENSP00000405733
  • ENST00000471858
  • ENSP00000418928
  • ENST00000490004
  • ENSP00000418801

Symbol
  • CD200R
  • CRTR2
  • MOX2R
  • OX2R
  • OX2R
  • MOX2R
  • CD200R
  • HCRTR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
protein domain
0.58
gene perturbation
0.56
tissue
0.56
microRNA
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.15   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 608   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.15   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
CD200
Tbio
Novelty:  0.00075974
Score:  0.999
Data Source:  Reactome,STRINGDB
CD200R1L
Tdark
Novelty:  0.25041903
Score:  0.815
Data Source:  STRINGDB
DOK2
Tbio
Novelty:  0.02651438
Score:  0.777
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.717
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.712
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.693
Data Source:  STRINGDB
TLR2
Tchem
Novelty:  0.00023242
Score:  0.665
Data Source:  STRINGDB
CD300LF
Tbio
Novelty:  0.01373075
Score:  0.646
Data Source:  STRINGDB
TNFRSF11A
Tbio
Novelty:  0.0056219
Score:  0.64
Data Source:  STRINGDB
CX3CR1
Tchem
Family:  GPCR
Novelty:  0.00114874
Score:  0.608
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
77.1
eosinophil percentage of leukocytes
2
2
2
66.3
blood protein measurement
1
1
1
64.8
sum of eosinophil and basophil counts
1
1
1
30.9
asthma
1
1
0
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
77.1
eosinophil percentage of leukocytes
2
66.3
blood protein measurement
1
64.8
sum of eosinophil and basophil counts
1
30.9
asthma
0
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD200 receptor 1
VGNC:1765
743604
Macaque
CD200 receptor 1
708734
Rat
RGD:61837
64357
Cow
CD200 receptor 1-like
516008
Pig
cell surface glycoprotein CD200 receptor 2 precursor [Source:RefSeq peptide;Acc:NP_001231344]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD200 receptor 1
Macaque
CD200 receptor 1
Rat
Cow
CD200 receptor 1-like
Pig
cell surface glycoprotein CD200 receptor 2 precursor [Source:RefSeq peptide;Acc:NP_001231344]
Publication Statistics
PubMed Score 147.15
PubMed score by year
PubTator Score 53.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title