Tbio CD1E T-cell surface glycoprotein CD1e, membrane-associated

Protein Summary

Description

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P15812
• B4DZV3
• E7EP01
• Q5TDJ9
• Q5TDK3
• Q5TDK4
• Q5TDK5
• Q5TDK6
• Q5TDK8
• Q5TDL1
• Q712E4
• Q712E5
• Q712E6
• Q712E7
• Q712E8
• Q712E9
• Q712F0
• Q712F1
• Q712F2
• Q712F3
• Q712F4
• Q712F5
• Q96TD0
• Q96TD1
• Q9UMM1
• Q9Y5M3
• hCD1e

Gene Name

• CD1E

Ensembl ID

• ENST00000368154
• ENSP00000357136
• ENSG00000158488
• ENST00000368155
• ENSP00000357137
• ENST00000368156
• ENSP00000357138
• ENST00000368157
• ENSP00000357139
• ENST00000368160
• ENSP00000357142
• ENST00000368161
• ENSP00000357143
• ENST00000368163
• ENSP00000357145
• ENST00000368164
• ENSP00000357146
• ENST00000368165
• ENSP00000357147
• ENST00000368166
• ENSP00000357148
• ENST00000368167
• ENSP00000357149
• ENST00000444681
• ENSP00000402906
• ENST00000452291
• ENSP00000416228

Symbol

• R2
• CD1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.74
cell type or tissue	0.73
protein domain	0.73
metabolite	0.62
microRNA	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 562.35   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 562.35   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (133)

Explore Interacting Targets

1 – 10 of 133

• See Interactions on String-DB

FCGRT

Tclin

Novelty:  0.00105713

p_int:  0.999954286

p_ni:  0.000045713

Score:  0.301

Data Source:  BioPlex,STRINGDB

SUSD5

Tdark

Novelty:  1.0992718

p_int:  0.999333424

p_ni:  0.000664679

p_wrong:  0.000001897

Data Source:  BioPlex

FNDC3A

Tbio

Novelty:  0.04721453

p_int:  0.997920903

p_ni:  0.002079097

Data Source:  BioPlex

C1QL1

Tdark

Novelty:  0.11689088

p_int:  0.997490289

p_ni:  0.002509708

p_wrong:  3e-9

Data Source:  BioPlex

TMEM59L

Tbio

Novelty:  0.22745646

p_int:  0.996733735

p_ni:  0.003089988

p_wrong:  0.000176276

Data Source:  BioPlex

CANX

Tbio

Novelty:  0.00087002

p_int:  0.996536101

p_ni:  0.003463899

Score:  0.18

Data Source:  BioPlex,STRINGDB

DPAGT1

Tbio

Family:  Enzyme

Novelty:  0.00869839

p_int:  0.994886413

p_ni:  0.000003312

p_wrong:  0.005110275

Score:  0.185

Data Source:  BioPlex,STRINGDB

CTAGE5

Tbio

Novelty:  0.04516631

p_int:  0.993574675

p_ni:  0.006425321

p_wrong:  5e-9

Data Source:  BioPlex

B2M

Tbio

Novelty:  0.00011248

p_int:  0.990978394

p_ni:  0.009021497

p_wrong:  1.09e-7

Score:  0.795

Data Source:  BioPlex,STRINGDB

KCNJ8

Tbio

Family:  IC

Novelty:  0.00369886

p_int:  0.98968367

p_ni:  0.010316329

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

KEGG (3)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Tight junction	169 targets	path:hsa04530
KEGG	Amoebiasis	104 targets	path:hsa05146
KEGG	Hematopoietic cell lineage	108 targets	path:hsa04640

Name	Explore in Pharos	Explore in Source
Tight junction	169 targets	path:hsa04530
Amoebiasis	104 targets	path:hsa05146
Hematopoietic cell lineage	108 targets	path:hsa04640

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (3)

Components (7)

Processes (5)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
endogenous lipid antigen binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
exogenous lipid antigen binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lipopeptide binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	2	1	2		17.6
reticulocyte measurement	EFO_0010700	1	1	1		13.1
HbA1c measurement	EFO_0004541	1	1	1		10
neurofilament light chain measurement	EFO_0009178	1	1	0	1	2.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	2		17.6
reticulocyte measurement	EFO_0010700	1		13.1
HbA1c measurement	EFO_0004541	1		10
neurofilament light chain measurement	EFO_0009178	0	1	2.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Adaptive immunity
Alternative splicing
Complete proteome
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Immunity
Immunoglobulin domain

GWAS Trait Find Similar Targets

No Header	No Header
HbA1c measurement
neurofilament light chain measurement
reticulocyte count
reticulocyte measurement

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD1e molecule	VGNC:5018	457421
Macaque	CD1e molecule		718968
Dog	CD1e molecule	VGNC:38936	488610
Horse	CD1e2 molecule		100056437
Cow	CD1e molecule	VGNC:27008	510832

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD1e molecule
Macaque	CD1e molecule
Dog	CD1e molecule
Horse	CD1e2 molecule
Cow	CD1e molecule

Publication Statistics

PubMed Score 562.35

PubMed score by year

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PubTator Score 197.29

PubTator score by year

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Related Publications

Text Mined References (34)

GeneRif Annotations (19)

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10

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PMID	Year	Title