Tbio CD1E T-cell surface glycoprotein CD1e, membrane-associated

Protein Summary

Description

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P15812
• B4DZV3
• E7EP01
• Q5TDJ9
• Q5TDK3
• Q5TDK4
• Q5TDK5
• Q5TDK6
• Q5TDK8
• Q5TDL1
• Q712E4
• Q712E5
• Q712E6
• Q712E7
• Q712E8
• Q712E9
• Q712F0
• Q712F1
• Q712F2
• Q712F3
• Q712F4
• Q712F5
• Q96TD0
• Q96TD1
• Q9UMM1
• Q9Y5M3
• hCD1e

Gene Name

• CD1E

Ensembl ID

• ENST00000368154
• ENSP00000357136
• ENSG00000158488
• ENST00000368155
• ENSP00000357137
• ENST00000368156
• ENSP00000357138
• ENST00000368157
• ENSP00000357139
• ENST00000368160
• ENSP00000357142
• ENST00000368161
• ENSP00000357143
• ENST00000368163
• ENSP00000357145
• ENST00000368164
• ENSP00000357146
• ENST00000368165
• ENSP00000357147
• ENST00000368166
• ENSP00000357148
• ENST00000368167
• ENSP00000357149
• ENST00000444681
• ENSP00000402906
• ENST00000452291
• ENSP00000416228

Symbol

• R2
• CD1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.74
cell type or tissue	0.73
protein domain	0.73
metabolite	0.62
microRNA	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 671.51   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 671.51   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0