Tclin CD19 B-lymphocyte antigen CD19

Protein Summary

Description

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15391
• A0N0P9
• F5H635
• Q96S68
• Q9BRD6

Gene Name

• CD19

Ensembl ID

• ENST00000324662
• ENSP00000313419
• ENSG00000177455
• ENST00000538922
• ENSP00000437940
• ENST00000567541
• ENSP00000456201

Symbol

• B4
• CVID3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.89
hub protein	0.79
cell type or tissue	0.76
cellular component	0.7
biological term	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6409.65   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 3891   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6409.65   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 3891   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4