Protein Summary
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
- ENST00000324662
- ENSP00000313419
- ENSG00000177455
- ENST00000538922
- ENSP00000437940
- ENST00000567541
- ENSP00000456201
- B4
- CVID3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.89 | ||
hub protein | 0.79 | ||
cell type or tissue | 0.76 | ||
cellular component | 0.7 | ||
biological term | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5336.19 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 3891 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5336.19 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 3891 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (0)
Protein-Protein Interactions (430)
Q6EEV4
Family: Enzyme
Novelty: 0.11413088
p_int: 0.999972195
p_ni: 0.000027805
Score: 0.169
Data Source: BioPlex,STRINGDB
MINDY3
Novelty: 0.02865765
p_int: 0.999499256
p_ni: 0.000500744
Score: 0.207
Data Source: BioPlex,STRINGDB
B3GNT3
Family: Enzyme
Novelty: 0.04325325
p_int: 0.998629257
p_ni: 0.000136099
p_wrong: 0.001234644
Score: 0.218
Data Source: BioPlex,STRINGDB
IGSF8
Novelty: 0.03016623
p_int: 0.938865204
p_ni: 0.061134794
p_wrong: 2e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (30)
Reactome (17)
KEGG (5)
PathwayCommons (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | Complement cascade | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Complement cascade | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 17 | 7 | 26 | 3.6 | 98.5 | ||||
mathematical ability | 3 | 2 | 3 | 91.4 | |||||
intelligence | 7 | 9 | 4 | 6 | 90.3 | ||||
grip strength measurement | 2 | 2 | 2 | 88.9 | |||||
waist-hip ratio | 3 | 2 | 3 | 86.8 | |||||
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 26 | 3.6 | 98.5 | ||||
mathematical ability | 3 | 91.4 | |||||
intelligence | 4 | 6 | 90.3 | ||||
grip strength measurement | 2 | 88.9 | |||||
waist-hip ratio | 3 | 86.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD19 molecule | VGNC:5705 | 454020 | |||||
Macaque | CD19 molecule | 705211 | ||||||
Mouse | MGI:88319 | 12478 | ||||||
Rat | RGD:1309086 | 365367 | ||||||
Dog | CD19 molecule | VGNC:38935 | 607898 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD19 molecule | |||||
Macaque | CD19 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD19 molecule | |||||
Publication Statistics
PubMed Score 5336.19
PubMed score by year
PubTator Score 2593.74
PubTator score by year
Related Publications
Text Mined References (121)
GeneRif Annotations (84)
Items per page:
0 of 0
PMID | Year | Title |
|---|