Protein Summary
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
- ENST00000324662
- ENSP00000313419
- ENSG00000177455
- ENST00000538922
- ENSP00000437940
- ENST00000567541
- ENSP00000456201
- B4
- CVID3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.89 | ||
hub protein | 0.79 | ||
cell type or tissue | 0.76 | ||
cellular component | 0.7 | ||
biological term | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5336.19 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 3891 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5336.19 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 3891 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (4)
Active Ligands (0)
Protein-Protein Interactions (430)
Q6EEV4
Family: Enzyme
Novelty: 0.11413088
p_int: 0.999972195
p_ni: 0.000027805
Score: 0.169
Data Source: BioPlex,STRINGDB
MINDY3
Novelty: 0.02865765
p_int: 0.999499256
p_ni: 0.000500744
Score: 0.207
Data Source: BioPlex,STRINGDB
B3GNT3
Family: Enzyme
Novelty: 0.04325325
p_int: 0.998629257
p_ni: 0.000136099
p_wrong: 0.001234644
Score: 0.218
Data Source: BioPlex,STRINGDB
IGSF8
Novelty: 0.03016623
p_int: 0.938865204
p_ni: 0.061134794
p_wrong: 2e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (30)
Reactome (17)
KEGG (5)
PathwayCommons (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | Complement cascade | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Complement cascade | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 17 | 7 | 26 | 3.6 | 98.5 | ||||
mathematical ability | 3 | 2 | 3 | 91.4 | |||||
intelligence | 7 | 9 | 4 | 6 | 90.3 | ||||
grip strength measurement | 2 | 2 | 2 | 88.9 | |||||
waist-hip ratio | 3 | 2 | 3 | 86.8 | |||||
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 26 | 3.6 | 98.5 | ||||
mathematical ability | 3 | 91.4 | |||||
intelligence | 4 | 6 | 90.3 | ||||
grip strength measurement | 2 | 88.9 | |||||
waist-hip ratio | 3 | 86.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD19 molecule | VGNC:5705 | 454020 | |||||
Macaque | CD19 molecule | 705211 | ||||||
Mouse | MGI:88319 | 12478 | ||||||
Rat | RGD:1309086 | 365367 | ||||||
Dog | CD19 molecule | VGNC:38935 | 607898 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD19 molecule | |||||
Macaque | CD19 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD19 molecule | |||||
Publication Statistics
PubMed Score 5336.19
PubMed score by year
PubTator Score 2593.74
PubTator score by year
Related Publications
Text Mined References (121)
GeneRif Annotations (84)
Items per page:
0 of 0
PMID | Year | Title |
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