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Tbio
CD177
CD177 antigen

Protein Summary
Description
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). This gene encodes a glycosyl-phosphatidylinositol (GPI) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378012
  • ENSP00000367251
  • ENSG00000204936

Symbol
  • NB1
  • PRV1
  • NB1
  • PRV1
  • HNA2A
  • PRV-1
  • HNA-2a
  • NB1 GP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.67
biological term
0.53
cellular component
0.53
tissue
0.52
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.6   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.6   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.974
Data Source:  Reactome,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.969
Data Source:  STRINGDB
PECAM1
Tbio
Novelty:  0.00013373
Score:  0.964
Data Source:  Reactome,STRINGDB
SLC44A2
Tbio
Family:  Transporter
Novelty:  0.01550561
Score:  0.937
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.937
Data Source:  STRINGDB
CEACAM8
Tbio
Novelty:  0.00370138
Score:  0.937
Data Source:  STRINGDB
CEACAM1
Tbio
Novelty:  0.0029954
Score:  0.933
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.93
Data Source:  STRINGDB
CD59
Tbio
Novelty:  0.0008352
Score:  0.926
Data Source:  STRINGDB
CLEC4D
Tbio
Novelty:  0.04119682
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cotinine glucuronidation measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cotinine glucuronidation measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
CD177 molecule
VGNC:38934
612424
Cow
CD177 molecule
VGNC:27006
616350
Species
Name
OMA
EggNOG
Inparanoid
Dog
CD177 molecule
Cow
CD177 molecule
Publication Statistics
PubMed Score 517.60
PubMed score by year
PubTator Score 570.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title