Tbio CD151 CD151 antigen

Protein Summary

Description

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48509
• A8KAK8
• E9PI15
• Q14826
• Q86U54
• Q96TE3

Gene Name

• CD151

Ensembl ID

• ENST00000322008
• ENSP00000324101
• ENSG00000177697
• ENST00000397420
• ENSP00000380565
• ENST00000397421
• ENSP00000380566
• ENST00000530726
• ENSP00000432385

Symbol

• TSPAN24
• GP27
• MER2
• RAPH
• SFA1
• PETA-3
• TSPAN24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
tissue	0.78
PubMedID	0.76
biological term	0.75
disease	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.35   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 607   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 420.35   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 607   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0