Protein Summary
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein ...more
- ENST00000322008
- ENSP00000324101
- ENSG00000177697
- ENST00000397420
- ENSP00000380565
- ENST00000397421
- ENSP00000380566
- ENST00000530726
- ENSP00000432385
- TSPAN24
- GP27
- MER2
- RAPH
- SFA1
- PETA-3
- TSPAN24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.88 | ||
tissue | 0.78 | ||
PubMedID | 0.76 | ||
biological term | 0.75 | ||
disease | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 357.32 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 607 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 357.32 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 607 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (75)
ITGA6
Novelty: 0.00217985
p_int: 0.999922571
p_ni: 0.000077377
p_wrong: 5.3e-8
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
ITGB2
Novelty: 0.00185859
p_int: 0.998628095
p_ni: 0.00079667
p_wrong: 0.000575236
Data Source: BioPlex
LRRC52
Family: IC
Novelty: 0.15407898
p_int: 0.895421423
p_ni: 0.007220608
p_wrong: 0.097357969
Data Source: BioPlex
TMPRSS11B
Family: Enzyme
Novelty: 1.20690443
p_int: 0.891104397
p_ni: 0.002720751
p_wrong: 0.106174853
Data Source: BioPlex
NCEH1
Family: Enzyme
Novelty: 0.01528589
p_int: 0.875548091
p_ni: 0.001198995
p_wrong: 0.123252914
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (6)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (1)
Components (7)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 5 | 6 | 91.5 | |||||
mean platelet volume | 2 | 2 | 2 | 89.4 | |||||
intraocular pressure measurement | 2 | 3 | 3 | 89 | |||||
waist-hip ratio | 4 | 6 | 9 | 86.9 | |||||
2 | 2 | 1 | 6.6 | 82.1 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 91.5 | |||||
mean platelet volume | 2 | 89.4 | |||||
intraocular pressure measurement | 3 | 89 | |||||
waist-hip ratio | 9 | 86.9 | |||||
1 | 6.6 | 82.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD151 molecule | VGNC:11284 | 740513 | |||||
Mouse | MGI:1096360 | 12476 | ||||||
Rat | RGD:621290 | 64315 | ||||||
Dog | CD151 molecule | VGNC:51858 | 475992 | |||||
Horse | CD151 molecule (Raph blood group) | 100056151 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD151 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD151 molecule | |||||
Horse | CD151 molecule (Raph blood group) | |||||
Publication Statistics
PubMed Score 357.32
PubMed score by year
PubTator Score 193.45
PubTator score by year
Related Publications
Text Mined References (130)
GeneRif Annotations (103)
Items per page:
0 of 0
PMID | Year | Title |
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