Tbio CD109 CD109 antigen

Protein Summary

Description

Modulates negatively TGFB1 signaling in keratinocytes. This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q6YHK3
• A5YKK4
• B2R948
• B3KW25
• Q0P6K7
• Q5SYA8
• Q5XUM7
• Q5XUM9
• Q6MZI7
• Q8N3A7
• Q8N915
• Q8TDJ2
• Q8TDJ3

Gene Name

• CD109

Ensembl ID

• ENST00000287097
• ENSP00000287097
• ENSG00000156535
• ENST00000422508
• ENSP00000404475
• ENST00000437994
• ENSP00000388062

Symbol

• CPAMD7
• p180
• r150
• CPAMD7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.85
kinase perturbation	0.81
PubMedID	0.79
histone modification site profile	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.76   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.76   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0