Protein Summary
Modulates negatively TGFB1 signaling in keratinocytes. This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
- ENST00000287097
- ENSP00000287097
- ENSG00000156535
- ENST00000422508
- ENSP00000404475
- ENST00000437994
- ENSP00000388062
- CPAMD7
- p180
- r150
- CPAMD7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
virus perturbation | 0.85 | ||
kinase perturbation | 0.81 | ||
PubMedID | 0.79 | ||
histone modification site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 109.76 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 337 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 109.76 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 337 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (117)
LGALS3
Novelty: 0.00032754
p_int: 0.999980968
p_ni: 0.000019031
p_wrong: 1e-9
Score: 0.373
Data Source: BioPlex,STRINGDB
LGALS9
Novelty: 0.00381766
p_int: 0.998612817
p_ni: 0.001387183
Score: 0.34
Data Source: BioPlex,STRINGDB
CAPN2
Novelty: 0.00431673
p_int: 0.99307205
p_ni: 0.006927929
p_wrong: 2.1e-8
Data Source: BioPlex
UCN3
Novelty: 0.00996251
p_int: 0.990337088
p_ni: 0.00966283
p_wrong: 8.1e-8
Data Source: BioPlex
CYP19A1
Family: Enzyme
Novelty: 0.0003187
p_int: 0.987692325
p_ni: 0.012307675
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
TAZ
Novelty: 0.00372301
p_int: 0.986713644
p_ni: 0.013286313
p_wrong: 4.3e-8
Data Source: BioPlex
PSCA
Novelty: 0.00323778
p_int: 0.986438387
p_ni: 0.013561588
p_wrong: 2.5e-8
Score: 0.9
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Metabolism of proteins | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 5 | 7 | 96.9 | |||||
calcium measurement | 3 | 3 | 3 | 94.1 | |||||
CD109 antigen measurement | 2 | 3 | 3 | 89.8 | |||||
2 | 2 | 2 | 29.5 | ||||||
angina pectoris | 1 | 1 | 1 | 1.6 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 7 | 96.9 | |||||
calcium measurement | 3 | 94.1 | |||||
CD109 antigen measurement | 3 | 89.8 | |||||
2 | 29.5 | ||||||
angina pectoris | 1 | 1.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD109 molecule | VGNC:2656 | 462825 | |||||
Macaque | CD109 molecule | 716136 | ||||||
Mouse | MGI:2445221 | 235505 | ||||||
Rat | RGD:1311287 | 363104 | ||||||
Dog | CD109 molecule | VGNC:38929 | 474970 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD109 molecule | |||||
Macaque | CD109 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD109 molecule | |||||
Publication Statistics
PubMed Score 109.76
PubMed score by year
PubTator Score 58.45
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
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