Tbio CD109 CD109 antigen

Protein Summary

Description

Modulates negatively TGFB1 signaling in keratinocytes. This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q6YHK3
• A5YKK4
• B2R948
• B3KW25
• Q0P6K7
• Q5SYA8
• Q5XUM7
• Q5XUM9
• Q6MZI7
• Q8N3A7
• Q8N915
• Q8TDJ2
• Q8TDJ3

Gene Name

• CD109

Ensembl ID

• ENST00000287097
• ENSP00000287097
• ENSG00000156535
• ENST00000422508
• ENSP00000404475
• ENST00000437994
• ENSP00000388062

Symbol

• CPAMD7
• p180
• r150
• CPAMD7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.85
kinase perturbation	0.81
PubMedID	0.79
histone modification site profile	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.34   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.34   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (117)

Explore Interacting Targets

1 – 10 of 117

• See Interactions on String-DB

CAPN1

Tchem

Novelty:  0.00252811

p_int:  0.999999895

p_ni:  9.6e-8

p_wrong:  9e-9

Data Source:  BioPlex

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.999980968

p_ni:  0.000019031

p_wrong:  1e-9

Score:  0.373

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.998612817

p_ni:  0.001387183

Score:  0.34

Data Source:  BioPlex,STRINGDB

SCGB1D1

Tbio

Novelty:  0.04199997

p_int:  0.998255239

p_ni:  0.001744761

Data Source:  BioPlex

CAPN2

Tchem

Novelty:  0.00431673

p_int:  0.99307205

p_ni:  0.006927929

p_wrong:  2.1e-8

Data Source:  BioPlex

HYOU1

Tbio

Novelty:  0.00833649

p_int:  0.99042235

p_ni:  0.00957765

p_wrong:  1e-9

Data Source:  BioPlex

UCN3

Tbio

Novelty:  0.00996251

p_int:  0.990337088

p_ni:  0.00966283

p_wrong:  8.1e-8

Data Source:  BioPlex

CYP19A1

Tclin

Family:  Enzyme

Novelty:  0.0003187

p_int:  0.987692325

p_ni:  0.012307675

p_wrong:  1e-9

Score:  0.173

Data Source:  BioPlex,STRINGDB

TAZ

Tbio

Novelty:  0.00372301

p_int:  0.986713644

p_ni:  0.013286313

p_wrong:  4.3e-8

Data Source:  BioPlex

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.986438387

p_ni:  0.013561588

p_wrong:  2.5e-8

Score:  0.9

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (7)

Hemostasis (R-HSA-109582)

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1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Reactome	Platelet degranulation	128 targets	R-HSA-114608
Reactome	Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125

Name	Explore in Pharos	Explore in Source
Hemostasis	666 targets	R-HSA-109582
Metabolism of proteins	2050 targets	R-HSA-392499
Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Platelet degranulation	128 targets	R-HSA-114608
Post-translational modification: synthesis of GPI-anchored proteins	94 targets	R-HSA-163125

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (6)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
transforming growth factor beta binding	Inferred from Physical Interaction (IPI)	UniProtKB
serine-type endopeptidase inhibitor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	4	6		95.5
calcium measurement	EFO_0004838	1	1	1		59.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	6		95.5
calcium measurement	EFO_0004838	1		59.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Bait region
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
calcium measurement
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
immune system phenotype
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD109 molecule	VGNC:2656	462825
Macaque	CD109 molecule		716136
Mouse	CD109 antigen	MGI:2445221	235505
Rat	CD109 molecule	RGD:1311287	363104
Dog	CD109 molecule	VGNC:38929	474970

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD109 molecule
Macaque	CD109 molecule
Mouse	CD109 antigen
Rat	CD109 molecule
Dog	CD109 molecule

Publication Statistics

PubMed Score 101.34

PubMed score by year

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PubTator Score 58.45

PubTator score by year

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Related Publications

Text Mined References (58)

GeneRif Annotations (43)

Items per page:

10

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PMID	Year	Title