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Tdark
CCT6B
T-complex protein 1 subunit zeta-2

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314144
  • ENSP00000327191
  • ENSG00000132141
  • ENST00000421975
  • ENSP00000398044
  • ENST00000436961
  • ENSP00000400917

Symbol
  • Cctz2
  • CCTZ-2
  • TSA303
  • CCT-zeta-2
  • TCP-1-zeta-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
protein domain
0.92
molecular function
0.86
transcription factor binding site profile
0.82
cell type or tissue
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (261)
WDR77
Tbio
Novelty:  0.03052382
p_int:  0.998321594
p_ni:  0.001678406
Score:  0.195
Data Source:  BioPlex,STRINGDB
DAZ2
Tbio
p_int:  0.998113188
p_ni:  0.001886812
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.997633505
p_ni:  0.002366495
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYH7B
Tbio
Novelty:  0.00864941
p_int:  0.997235502
p_ni:  0.002764498
Data Source:  BioPlex
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.997165428
p_ni:  0.002834572
Score:  0.198
Data Source:  BioPlex,STRINGDB
CERCAM
Tdark
Family:  Enzyme
Novelty:  0.33392502
p_int:  0.996560694
p_ni:  0.003439306
Data Source:  BioPlex
KLHDC8A
Tdark
Novelty:  1.43751731
p_int:  0.996492284
p_ni:  0.003507716
Data Source:  BioPlex
PEX7
Tbio
Novelty:  0.01487923
p_int:  0.995903784
p_ni:  0.004096216
Score:  0.263
Data Source:  BioPlex,STRINGDB
THOC3
Tbio
Novelty:  0.04716962
p_int:  0.995214168
p_ni:  0.004785832
Data Source:  BioPlex
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.994226086
p_ni:  0.005773914
Score:  0.222
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Folding of actin by CCT/TriC
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Folding of actin by CCT/TriC
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
2
1
0
1.2
57.8
macrophage inflammatory protein 1b measurement
1
1
1
48.5
pulse pressure measurement
1
1
1
45.7
electrocardiography
1
1
17
40.7
TPE interval measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.2
57.8
macrophage inflammatory protein 1b measurement
1
48.5
pulse pressure measurement
1
45.7
electrocardiography
17
40.7
TPE interval measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 6B
VGNC:9173
468211
Horse
chaperonin containing TCP1 subunit 6B
VGNC:16240
100058222
Cow
chaperonin containing TCP1 subunit 6B
VGNC:26999
538090
C. elegans
175819
Fruitfly
FBgn0027329
32518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 6B
Horse
chaperonin containing TCP1 subunit 6B
Cow
chaperonin containing TCP1 subunit 6B
C. elegans
Fruitfly
Publication Statistics
PubMed Score 4.85
PubMed score by year
PubTator Score 0.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title