You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCT6A
T-complex protein 1 subunit zeta

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275603
  • ENSP00000275603
  • ENSG00000146731
  • ENST00000335503
  • ENSP00000352019

Symbol
  • CCT6
  • CCTZ
  • CCT6
  • Cctz
  • HTR3
  • TCPZ
  • TCP20
  • MoDP-2
  • TTCP20
  • CCT-zeta
  • CCT-zeta-1
  • TCP-1-zeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
hub protein
0.99
disease perturbation
0.93
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (431)
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.997222137
p_ni:  0.002777863
Score:  0.162
Data Source:  BioPlex,STRINGDB
DNAI2
Tbio
Novelty:  0.02801096
p_int:  0.989584132
p_ni:  0.010415868
Score:  0.22
Data Source:  BioPlex,STRINGDB
KLHL33
Tdark
Novelty:  1.42677156
p_int:  0.988283555
p_ni:  0.011716445
Score:  0.183
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.986722952
p_ni:  0.013277048
Score:  0.999
Data Source:  BioPlex,STRINGDB
CERCAM
Tdark
Family:  Enzyme
Novelty:  0.33392502
p_int:  0.982386896
p_ni:  0.017613104
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.980692775
p_ni:  0.019307225
Score:  0.999
Data Source:  BioPlex,STRINGDB
FBXW4
Tbio
Novelty:  0.06255177
p_int:  0.978041231
p_ni:  0.021958769
Score:  0.923
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.971630516
p_ni:  0.028369484
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRDX2
Tbio
Novelty:  0.00189751
p_int:  0.971167258
p_ni:  0.028832742
Score:  0.254
Data Source:  BioPlex,STRINGDB
KLHDC8A
Tdark
Novelty:  1.43751731
p_int:  0.970966388
p_ni:  0.029033612
Score:  0.306
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Folding of actin by CCT/TriC
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Folding of actin by CCT/TriC
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
11
19
94.4
glycine measurement
3
2
3
90.8
lymphocyte count
2
2
2
86.1
blood metabolite measurement
2
1
2
69.8
myeloid white cell count
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
19
94.4
glycine measurement
3
90.8
lymphocyte count
2
86.1
blood metabolite measurement
2
69.8
myeloid white cell count
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 6A
VGNC:7357
463421
Macaque
chaperonin containing TCP1 subunit 6A
703326
Rat
RGD:1304763
288620
Dog
chaperonin containing TCP1 subunit 6A
VGNC:38926
606787
Horse
chaperonin containing TCP1 subunit 6A
VGNC:16239
100060692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 6A
Macaque
chaperonin containing TCP1 subunit 6A
Rat
Dog
chaperonin containing TCP1 subunit 6A
Horse
chaperonin containing TCP1 subunit 6A
Publication Statistics
PubMed Score 50.38
PubMed score by year
PubTator Score 13.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title