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Tbio
CCT2
T-complex protein 1 subunit beta

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299300
  • ENSP00000299300
  • ENSG00000166226
  • ENST00000543146
  • ENSP00000445471

Symbol
  • 99D8.1
  • CCTB
  • CCTB
  • 99D8.1
  • PRO1633
  • CCT-beta
  • HEL-S-100n
  • TCP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
kinase perturbation
1
disease perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (681)
WDR24
Tdark
Novelty:  0.48411996
p_int:  0.999999873
p_ni:  1.27e-7
Data Source:  BioPlex
KATNB1
Tbio
Novelty:  0.08472625
p_int:  0.999999546
p_ni:  4.54e-7
Data Source:  BioPlex
WDR70
Tdark
Novelty:  0.37521871
p_int:  0.999999535
p_ni:  4.65e-7
Data Source:  BioPlex
TUBD1
Tbio
Novelty:  0.03591414
p_int:  0.999999283
p_ni:  3.02e-7
p_wrong:  4.15e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
DCAF12
Tbio
Novelty:  0.15472702
p_int:  0.999999109
p_ni:  8.35e-7
p_wrong:  5.5e-8
Data Source:  BioPlex
DCAF13
Tbio
Novelty:  0.02796363
p_int:  0.999997282
p_ni:  0.000002707
p_wrong:  1.1e-8
Score:  0.289
Data Source:  BioPlex,STRINGDB
WDR25
Tdark
Novelty:  0.53632123
p_int:  0.999996329
p_ni:  0.000003357
p_wrong:  3.14e-7
Data Source:  BioPlex
RFWD3
Tbio
Family:  Enzyme
Novelty:  0.0859205
p_int:  0.999992686
p_ni:  0.000007314
Data Source:  BioPlex
KATNAL1
Tbio
Family:  Enzyme
Novelty:  0.11227609
p_int:  0.99998947
p_ni:  5.42e-7
p_wrong:  0.000009988
Data Source:  BioPlex
NEDD1
Tbio
Novelty:  0.03077131
p_int:  0.99998601
p_ni:  0.00001399
Score:  0.267
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
3
2
3
72.4
1
2
0
1.1
60.4
albuminuria
2
1
2
49.5
Moderate albuminuria
1
1
0
1
48.5
sex hormone-binding globulin measurement
2
2
2
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
3
72.4
0
1.1
60.4
albuminuria
2
49.5
Moderate albuminuria
0
1
48.5
sex hormone-binding globulin measurement
2
46
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 2
VGNC:8397
452071
Macaque
chaperonin containing TCP1 subunit 2
717182
Mouse
MGI:107186
12461
Rat
RGD:1359143
299809
Dog
chaperonin containing TCP1 subunit 2
VGNC:38922
474445
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 2
Macaque
chaperonin containing TCP1 subunit 2
Mouse
Rat
Dog
chaperonin containing TCP1 subunit 2
Publication Statistics
PubMed Score 56.63
PubMed score by year
PubTator Score 25.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title