You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CCR7
C-C chemokine receptor type 7

Protein Summary
Description
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246657
  • ENSP00000246657
  • ENSG00000126353

Symbol
  • CMKBR7
  • EBI1
  • EVI1
  • BLR2
  • EBI1
  • CCR-7
  • CD197
  • CDw197
  • CMKBR7
  • CC-CKR-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.84
PubMedID
0.82
phenotype
0.8
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1163.88   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 969   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1163.88   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 969   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (508)
CCL21
Tbio
Novelty:  0.00130736
Score:  0.997
Data Source:  Reactome,STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.996
Data Source:  Reactome,STRINGDB
S1PR4
Tclin
Family:  GPCR
Novelty:  0.01523676
Score:  0.972
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.972
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.972
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.971
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.969
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.968
Data Source:  STRINGDB
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
Score:  0.967
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.967
Data Source:  STRINGDB
Pathways (17)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (61)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.1
92
5
4
2
1.1
91.5
Eczema
3
2
0
1.3
83.5
3
2
0
1.3
83.5
lymphocyte percentage of leukocytes
2
2
3
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92
2
1.1
91.5
Eczema
0
1.3
83.5
0
1.3
83.5
lymphocyte percentage of leukocytes
3
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 7
VGNC:9171
454654
Macaque
C-C motif chemokine receptor 7
574231
Mouse
MGI:103011
12775
Rat
RGD:735151
287673
Dog
C-C motif chemokine receptor 7
VGNC:38915
491011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 7
Macaque
C-C motif chemokine receptor 7
Mouse
Rat
Dog
C-C motif chemokine receptor 7
Publication Statistics
PubMed Score 1163.88
PubMed score by year
PubTator Score 604.94
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title