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Tchem
CCR6
C-C chemokine receptor type 6

Protein Summary
Description
Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune respon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341935
  • ENSP00000343952
  • ENSG00000112486
  • ENST00000349984
  • ENSP00000339393
  • ENST00000400926
  • ENSP00000383715
  • ENST00000643861
  • ENSP00000493637

Symbol
  • CKRL3
  • CMKBR6
  • GPR29
  • STRL22
  • BN-1
  • DCR2
  • DRY6
  • CCR-6
  • CD196
  • CKRL3
  • GPR29
  • CKR-L3
  • CMKBR6
  • GPRCY4
  • STRL22
  • CC-CKR-6
  • C-C CKR-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.86
gene perturbation
0.76
PubMedID
0.76
phenotype
0.75
ligand (protein)
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.67   (req: < 5)
Gene RIFs: 165   (req: <= 3)
Antibodies: 771   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.67   (req: >= 5)
Gene RIFs: 165   (req: > 3)
Antibodies: 771   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0