Tclin CCR4 C-C chemokine receptor type 4

Protein Summary

Description

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51679
• Q9ULY6
• Q9ULY7
• C-C CKR-4

Gene Name

• CCR4

Ensembl ID

• ENST00000330953
• ENSP00000332659
• ENSG00000183813

Symbol

• CMKBR4
• CKR4
• K5-5
• CD194
• CMKBR4
• ChemR13
• CC-CKR-4
• HGCN:14099

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.85
phenotype	0.68
biological term	0.66
tissue	0.65
disease perturbation	0.62

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor Type 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.31   (req: < 5)

Gene RIFs: 93   (req: <= 3)

Antibodies: 696   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.31   (req: >= 5)

Gene RIFs: 93   (req: > 3)

Antibodies: 696   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 160

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2