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Tchem
CCR3
C-C chemokine receptor type 3

Protein Summary
Description
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357422
  • ENSP00000350003
  • ENSG00000183625
  • ENST00000395940
  • ENSP00000379271
  • ENST00000395942
  • ENSP00000379273
  • ENST00000545097
  • ENSP00000441600

Symbol
  • CMKBR3
  • CKR3
  • CD193
  • CMKBR3
  • CC-CKR-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
co-expressed gene
0.94
gene perturbation
0.76
biological term
0.73
disease
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.43   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 731   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 475.43   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 695
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (335)
CCL11
Tbio
Novelty:  0.00086805
Score:  0.999
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.992
Data Source:  Reactome,STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.983
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.982
Data Source:  STRINGDB
CCL26
Tbio
Novelty:  0.00556498
Score:  0.98
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.978
Data Source:  STRINGDB
CCL13
Tbio
Novelty:  0.00593527
Score:  0.977
Data Source:  Reactome,STRINGDB
CCL8
Tbio
Novelty:  0.00441336
Score:  0.976
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.974
Data Source:  STRINGDB
CCL24
Tbio
Novelty:  0.0071091
Score:  0.97
Data Source:  STRINGDB
Pathways (23)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (79)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
6
6
98.5
monocyte percentage of leukocytes
2
9
9
98.2
Oral ulcer
1
3
0
1.1
95.6
CCL2 measurement
3
4
4
91.3
5
6
1
1.3
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
6
98.5
monocyte percentage of leukocytes
9
98.2
Oral ulcer
0
1.1
95.6
CCL2 measurement
4
91.3
1
1.3
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 3
VGNC:8828
470810
Macaque
C-C motif chemokine receptor 3
713368
Mouse
MGI:104616
12771
Rat
RGD:620593
117027
Dog
C-C motif chemokine receptor 3
VGNC:38912
448802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor 3
Macaque
C-C motif chemokine receptor 3
Mouse
Rat
Dog
C-C motif chemokine receptor 3
Publication Statistics
PubMed Score 475.43
PubMed score by year
PubTator Score 339.03
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title