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Tbio
CCPG1
Cell cycle progression protein 1

Protein Summary
Description
Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310958
  • ENSP00000311656
  • ENSG00000260916
  • ENST00000425574
  • ENSP00000415128
  • ENST00000442196
  • ENSP00000403400
  • ENST00000569205
  • ENSP00000454456

Symbol
  • CCP8
  • CPR8
  • KIAA1254
  • CPR8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
ligand (protein) perturbation
0.83
histone modification site profile
0.81
transcription factor perturbation
0.8
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.999605189
p_ni:  0.000394811
Data Source:  BioPlex
KCNK16
Tbio
Family:  IC
Novelty:  0.09168043
p_int:  0.998051533
p_ni:  0.001948467
Data Source:  BioPlex
OR13J1
Tdark
Family:  oGPCR
Novelty:  2.15311005
p_int:  0.993721348
p_ni:  0.006278652
Data Source:  BioPlex
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
p_int:  0.992590689
p_ni:  0.007409311
Data Source:  BioPlex
SLC22A13
Tbio
Family:  Transporter
Novelty:  0.04702774
p_int:  0.992029594
p_ni:  0.007970406
Score:  0.209
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.984500099
p_ni:  0.015499901
Data Source:  BioPlex
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.982433067
p_ni:  0.017566933
Data Source:  BioPlex
TMED3
Tbio
Novelty:  0.06696993
p_int:  0.979151262
p_ni:  0.020848738
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.975886589
p_ni:  0.024113411
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.974249398
p_ni:  0.025750602
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell cycle progression 1
VGNC:3570
467688
Macaque
cell cycle progression 1
698918
Mouse
MGI:1196419
72278
Rat
RGD:1311261
363098
Dog
cell cycle progression 1
VGNC:38910
487566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell cycle progression 1
Macaque
cell cycle progression 1
Mouse
Rat
Dog
cell cycle progression 1
Publication Statistics
PubMed Score 12.12
PubMed score by year
PubTator Score 5.25
PubTator score by year
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Related Publications
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PMID
Year
Title