Tchem CCNT1 Cyclin-T1

Protein Summary

Description

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Accession IDs

• O60563
• A9XU13
• E7EX76
• O60581
• CycT1

Gene Name

• CCNT1

Ensembl ID

• ENST00000261900
• ENSP00000261900
• ENSG00000129315
• ENST00000417344
• ENSP00000399845
• ENST00000618666
• ENSP00000481035

Symbol

• CCNT
• CYCT1
• HIVE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
interacting protein	0.96
pathway	0.96
transcription factor binding site profile	0.95
biological process	0.86

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cyclin-t1

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Cyclin-t1

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-t1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-t1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.46   (req: < 5)

Gene RIFs: 80   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.46   (req: >= 5)

Gene RIFs: 80   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0