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Tchem
CCNT1
Cyclin-T1

Protein Summary
Description
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, whic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261900
  • ENSP00000261900
  • ENSG00000129315
  • ENST00000417344
  • ENSP00000399845
  • ENST00000618666
  • ENSP00000481035

Symbol
  • CCNT
  • CYCT1
  • HIVE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
interacting protein
0.96
pathway
0.96
transcription factor binding site profile
0.95
biological process
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.46   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.46   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (267)
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.999999821
p_ni:  1.79e-7
Score:  0.913
Data Source:  BioPlex,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.999999749
p_ni:  2.51e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HEXIM1
Tbio
Novelty:  0.0142443
p_int:  0.999996905
p_ni:  0.000002929
p_wrong:  1.66e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.99997841
p_ni:  0.000021523
p_wrong:  6.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ELL3
Tbio
Family:  Enzyme
Novelty:  0.18245631
p_int:  0.999971526
p_ni:  0.000028472
p_wrong:  1e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
p_int:  0.999615234
p_ni:  0.000384766
Score:  0.869
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.990251785
p_ni:  0.009659305
p_wrong:  0.00008891
Data Source:  BioPlex
TMEM150A
Tbio
Novelty:  0.12446897
p_int:  0.98491329
p_ni:  0.015086694
p_wrong:  1.6e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
CACNG2
Tbio
Family:  IC
Novelty:  0.00808502
p_int:  0.983987462
p_ni:  0.016012471
p_wrong:  6.7e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.961919937
p_ni:  0.023599249
p_wrong:  0.014480814
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Name
Explore in Pharos
Explore in Source
Disease
ESR-mediated signaling
Estrogen-dependent gene expression
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
3
3
90.6
lymphocyte count
2
2
2
49.4
leukocyte count
2
2
2
46
myeloid white cell count
1
1
1
37
heel bone mineral density
1
1
1
27.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
90.6
lymphocyte count
2
49.4
leukocyte count
2
46
myeloid white cell count
1
37
heel bone mineral density
1
27.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin T1
VGNC:5328
450146
Macaque
cyclin T1
707754
Mouse
MGI:1328363
12455
Rat
RGD:1311151
315291
Dog
cyclin T1
VGNC:38906
486564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin T1
Macaque
cyclin T1
Mouse
Rat
Dog
cyclin T1
Publication Statistics
PubMed Score 242.46
PubMed score by year
PubTator Score 165.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title