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Tbio
CCNL1
Cyclin-L1

Protein Summary
Description
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295925
  • ENSP00000295925
  • ENSG00000163660
  • ENST00000295926
  • ENSP00000295926
  • ENST00000461804
  • ENSP00000420277
  • ENST00000465947
  • ENSP00000418094
  • ENST00000470121
  • ENSP00000417237
  • ENST00000475298
  • ENSP00000417343
  • ENST00000477127
  • ENSP00000418449
  • ENST00000631619
  • ENSP00000487951

Symbol
  • ANIA6A
  • BM-001
  • PRO1073
  • ania-6a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.99
virus perturbation
0.99
drug perturbation
0.96
transcription factor perturbation
0.8
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
CDK11A
Tchem
Family:  Kinase
Novelty:  0.02312993
p_int:  1
Score:  0.821
Data Source:  BioPlex,STRINGDB
CDK11B
Tchem
Family:  Kinase
Novelty:  0.02711308
p_int:  0.99999997
p_ni:  3e-8
Score:  0.727
Data Source:  BioPlex,STRINGDB
SAP30BP
Tbio
Novelty:  0.12160951
p_int:  0.999284845
p_ni:  0.000715155
Score:  0.219
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.997521239
p_ni:  1.59e-7
p_wrong:  0.002478602
Score:  0.188
Data Source:  BioPlex,STRINGDB
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.912665123
p_ni:  0.087334877
Score:  0.46
Data Source:  BioPlex,STRINGDB
MCM2
Tbio
Novelty:  0.00276275
Score:  0.993
Data Source:  STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.949
Data Source:  STRINGDB
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
Score:  0.933
Data Source:  STRINGDB
CDK12
Tchem
Family:  Kinase
Novelty:  0.0119925
Score:  0.902
Data Source:  STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
Score:  0.889
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
6
15
98.1
waist-hip ratio
6
6
7
97.8
BMI-adjusted waist circumference
6
9
19
97.7
waist circumference
2
5
6
97.5
birth weight
7
3
7
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
15
98.1
waist-hip ratio
7
97.8
BMI-adjusted waist circumference
19
97.7
waist circumference
6
97.5
birth weight
7
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin L1
VGNC:1763
460805
Macaque
cyclin L1
705208
Mouse
MGI:1922664
56706
Rat
RGD:620864
114121
Dog
cyclin L1 [Source:HGNC Symbol;Acc:HGNC:20569]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin L1
Macaque
cyclin L1
Mouse
Rat
Dog
cyclin L1 [Source:HGNC Symbol;Acc:HGNC:20569]
Publication Statistics
PubMed Score 13.69
PubMed score by year
PubTator Score 18.34
PubTator score by year
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Related Publications
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PMID
Year
Title