Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

CCNJL

Ensembl ID

ENST00000393977
ENSP00000377547
ENSG00000135083

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.71

histone modification site profile	0.66

tissue sample	0.59

transcription factor perturbation	0.54

small molecule perturbation	0.53

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 109 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 109 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

See Interactions on String-DB

WDR74

Tbio

Novelty: 0.07119796

p_int: 0.997895289

p_ni: 0.001972516

p_wrong: 0.000132196

Score: 0.188

Data Source: BioPlex,STRINGDB

TROAP

Tbio

Novelty: 0.06268103

p_int: 0.991306599

p_ni: 0.008688139

p_wrong: 0.000005262

Score: 0.189

Data Source: BioPlex,STRINGDB

AP5B1

Tdark

Novelty: 0.06116142

p_int: 0.978472309

p_ni: 0.021516825

p_wrong: 0.000010866

Score: 0.163

Data Source: BioPlex,STRINGDB

TRMT44

Tdark

Family: Enzyme

Novelty: 0.27902923

p_int: 0.978370894

p_ni: 0.021629106

Score: 0.177

Data Source: BioPlex,STRINGDB

STIL

Tbio

Novelty: 0.01053211

p_int: 0.972667551

p_ni: 0.027332448

Data Source: BioPlex

FOXF2

Tbio

Family: TF

Novelty: 0.02032168

p_int: 0.959811882

p_ni: 0.034552903

p_wrong: 0.005635215

Score: 0.19

Data Source: BioPlex,STRINGDB

JMJD4

Tbio

Novelty: 0.09951585

p_int: 0.944029099

p_ni: 0.051104181

p_wrong: 0.00486672

Score: 0.244

Data Source: BioPlex,STRINGDB

MSTO1

Tbio

Novelty: 0.05914188

p_int: 0.938366898

p_ni: 0.061632517

p_wrong: 5.84e-7

Data Source: BioPlex

OS9

Tbio

Novelty: 0.01490339

p_int: 0.922191189

p_ni: 0.077808811

Data Source: BioPlex

PIK3C2A

Tchem

Family: Kinase

Novelty: 0.0002219

p_int: 0.907191335

p_ni: 0.092808665

Score: 0.257

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (2)

Components (3)

Processes (6)

Find Similar Targets

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

protein kinase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (8)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
platelet count	EFO_0004309	4	5	5	97.6

mean platelet volume	EFO_0004584	3	4	4	97.5

platelet crit	EFO_0007985	2	2	2	77.2

eosinophil count	EFO_0004842	1	1	1	62.1

hematological measurement	EFO_0004503	1	1	1	31.3

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
platelet count	EFO_0004309	5	97.6

mean platelet volume	EFO_0004584	4	97.5

platelet crit	EFO_0007985	2	77.2

eosinophil count	EFO_0004842	1	62.1

hematological measurement	EFO_0004503	1	31.3

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID
Chimp	cyclin J like	VGNC:6836	462234

Macaque	cyclin J like		695560

Mouse	cyclin J-like	MGI:2685723	380694

Rat	cyclin J-like	RGD:1561384	303059

Dog	cyclin-J-like protein		608987

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin J like

Macaque	cyclin J like

Mouse	cyclin J-like

Rat	cyclin J-like

Dog	cyclin-J-like protein

Publication Statistics

PubMed Score 0.33

PubMed score by year

Related Publications

Text Mined References (3)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Alternative splicing

Complete proteome

Cyclin

Polymorphism

Reference proteome

No Header	No Header
BMI-adjusted waist circumference

eosinophil count

heel bone mineral density

hematological measurement

household income

mean platelet volume

platelet count

platelet crit