Tbio CCNH Cyclin-H

Protein Summary

Description

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P51946
• Q53X72
• Q8TBL9

Gene Name

• CCNH

Ensembl ID

• ENST00000256897
• ENSP00000256897
• ENSG00000134480

Symbol

• CAK
• p34
• p37
• CycH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
biological process	0.93
molecular function	0.88
ligand (protein) perturbation	0.83
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cyclin-h

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Cyclin-h

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-h

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-h

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.1   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.1   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (277)

Explore Interacting Targets

1 – 10 of 277

• See Interactions on String-DB

CDK7

Tchem

Family:  Kinase

Novelty:  0.00322814

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

MNAT1

Tbio

Family:  Enzyme

Novelty:  0.02484936

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ERCC3

Tbio

Family:  Enzyme

Novelty:  0.00978601

p_int:  0.999999423

p_ni:  5.77e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

p_int:  0.999927499

p_ni:  0.000072501

Score:  0.986

Data Source:  BioPlex,Reactome,STRINGDB

PI15

Tbio

Family:  Enzyme

Novelty:  0.02244161

p_int:  0.999915859

p_ni:  0.000084013

p_wrong:  1.28e-7

Data Source:  BioPlex

ERCC5

Tchem

Family:  Enzyme

Novelty:  0.00819696

p_int:  0.999677744

p_ni:  2.25e-7

p_wrong:  0.000322031

Score:  0.99

Data Source:  BioPlex,STRINGDB

ABLIM3

Tdark

Novelty:  0.28184092

p_int:  0.998359206

p_ni:  0.001640746

p_wrong:  4.8e-8

Data Source:  BioPlex

CNOT3

Tbio

Novelty:  0.02463568

p_int:  0.998219925

p_ni:  0.001779077

p_wrong:  9.99e-7

Score:  0.217

Data Source:  BioPlex,STRINGDB

ERCC2

Tchem

Family:  Enzyme

Novelty:  0.00240155

p_int:  0.992986513

p_ni:  0.007013487

Score:  0.999

Data Source:  BioPlex,STRINGDB

CPSF4L

Tdark

Novelty:  4.27116708

p_int:  0.984199103

p_ni:  0.015745044

p_wrong:  0.000055853

Score:  0.265

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (73)

Reactome (60)

KEGG (3)

PathwayCommons (7)

WikiPathways (3)

Cell Cycle (R-HSA-1640170)

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Find Similar Targets

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5

1 – 5 of 60

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cyclin A/B1/B2 associated events during G2/M transition	25 targets	R-HSA-69273
Reactome	Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Reactome	Cyclin D associated events in G1	45 targets	R-HSA-69231

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cyclin A/B1/B2 associated events during G2/M transition	25 targets	R-HSA-69273
Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Cyclin D associated events in G1	45 targets	R-HSA-69231

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (2)

Components (5)

Processes (14)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
kinase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (6)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1	1	1		44.2
prostate carcinoma	EFO_0001663	1	1	1		28.1
Gleason score measurement	EFO_0007000	1	1	1		28.1
cancer aggressiveness measurement	EFO_0006999	1	1	1		28.1
type II diabetes mellitus	EFO_0001360	2	1	1	1	26.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1		44.2
prostate carcinoma	EFO_0001663	1		28.1
Gleason score measurement	EFO_0007000	1		28.1
cancer aggressiveness measurement	EFO_0006999	1		28.1
type II diabetes mellitus	EFO_0001360	1	1	26.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Complete proteome
Cyclin
Direct protein sequencing
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
body height
cancer aggressiveness measurement
chronotype measurement
Gleason score measurement
prostate carcinoma
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (17)

1 – 5 of 17

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cyclin H	VGNC:11871	739351
Macaque	cyclin H		694224
Mouse	cyclin H	MGI:1913921	66671
Rat	cyclin H	RGD:69419	84389
Dog	cyclin H	VGNC:38902	479156

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin H
Macaque	cyclin H
Mouse	cyclin H
Rat	cyclin H
Dog	cyclin H

Publication Statistics

PubMed Score 126.10

PubMed score by year

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PubTator Score 78.35

PubTator score by year

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Related Publications

Text Mined References (115)

GeneRif Annotations (23)

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PMID	Year	Title