Protein Summary
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with ...more
- ENST00000256897
- ENSP00000256897
- ENSG00000134480
- CAK
- p34
- p37
- CycH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.95 | ||
biological process | 0.93 | ||
molecular function | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
virus perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.1 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 479 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.1 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 479 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (277)
CDK7
Family: Kinase
Novelty: 0.00322814
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MNAT1
Family: Enzyme
Novelty: 0.02484936
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ERCC3
Family: Enzyme
Novelty: 0.00978601
p_int: 0.999999423
p_ni: 5.77e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.999927499
p_ni: 0.000072501
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
PI15
Family: Enzyme
Novelty: 0.02244161
p_int: 0.999915859
p_ni: 0.000084013
p_wrong: 1.28e-7
Data Source: BioPlex
ERCC5
Family: Enzyme
Novelty: 0.00819696
p_int: 0.999677744
p_ni: 2.25e-7
p_wrong: 0.000322031
Score: 0.99
Data Source: BioPlex,STRINGDB
ABLIM3
Novelty: 0.28184092
p_int: 0.998359206
p_ni: 0.001640746
p_wrong: 4.8e-8
Data Source: BioPlex
CNOT3
Novelty: 0.02463568
p_int: 0.998219925
p_ni: 0.001779077
p_wrong: 9.99e-7
Score: 0.217
Data Source: BioPlex,STRINGDB
ERCC2
Family: Enzyme
Novelty: 0.00240155
p_int: 0.992986513
p_ni: 0.007013487
Score: 0.999
Data Source: BioPlex,STRINGDB
CPSF4L
Novelty: 4.27116708
p_int: 0.984199103
p_ni: 0.015745044
p_wrong: 0.000055853
Score: 0.265
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (73)
Reactome (60)
KEGG (3)
PathwayCommons (7)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cyclin A/B1/B2 associated events during G2/M transition | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Reactome | Cyclin D associated events in G1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cyclin A/B1/B2 associated events during G2/M transition | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Cyclin D associated events in G1 | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (2)
Components (5)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 1 | 1 | 44.2 | |||||
1 | 1 | 1 | 28.1 | ||||||
Gleason score measurement | 1 | 1 | 1 | 28.1 | |||||
cancer aggressiveness measurement | 1 | 1 | 1 | 28.1 | |||||
2 | 1 | 1 | 1 | 26.1 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 44.2 | |||||
1 | 28.1 | ||||||
Gleason score measurement | 1 | 28.1 | |||||
cancer aggressiveness measurement | 1 | 28.1 | |||||
1 | 1 | 26.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin H | VGNC:11871 | 739351 | |||||
Macaque | cyclin H | 694224 | ||||||
Mouse | MGI:1913921 | 66671 | ||||||
Rat | RGD:69419 | 84389 | ||||||
Dog | cyclin H | VGNC:38902 | 479156 | |||||
Publication Statistics
PubMed Score 126.10
PubMed score by year
PubTator Score 78.35
PubTator score by year
Related Publications
Text Mined References (115)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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