Tbio CCNH Cyclin-H

Protein Summary

Description

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P51946
• Q53X72
• Q8TBL9

Gene Name

• CCNH

Ensembl ID

• ENST00000256897
• ENSP00000256897
• ENSG00000134480

Symbol

• CAK
• p34
• p37
• CycH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
biological process	0.93
molecular function	0.88
ligand (protein) perturbation	0.83
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cyclin-h

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Cyclin-h

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-h

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-h

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.52   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.52   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0