Protein Summary
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000340828
- ENSP00000344635
- ENSG00000113328
- ENST00000393929
- ENSP00000377506
- ENST00000512163
- ENSP00000424315
- CCNG
- CYCG1
- CCNG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
transcription factor binding site profile | 0.78 | ||
PubMedID | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.81 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 278 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.81 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 278 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (115)
CPSF4L
Novelty: 4.27116708
p_int: 0.999991261
p_ni: 7.2e-8
p_wrong: 0.000008667
Score: 0.218
Data Source: BioPlex,STRINGDB
PPP2R5D
Family: Enzyme
Novelty: 0.03990599
p_int: 0.994294237
p_ni: 0.005705762
Score: 0.388
Data Source: BioPlex,STRINGDB
PPP2R5E
Family: Enzyme
Novelty: 0.05974697
p_int: 0.992336295
p_ni: 0.007663705
Score: 0.376
Data Source: BioPlex,STRINGDB
ZZEF1
Novelty: 0.33216648
p_int: 0.976119544
p_ni: 0.023880456
Score: 0.152
Data Source: BioPlex,STRINGDB
CUL4A
Novelty: 0.00917788
p_int: 0.952972969
p_ni: 0.047027031
Score: 0.322
Data Source: BioPlex,STRINGDB
CUL4B
Novelty: 0.0133075
p_int: 0.942702166
p_ni: 0.057297834
Score: 0.305
Data Source: BioPlex,STRINGDB
PPP2R5C
Family: Enzyme
Novelty: 0.03336609
p_int: 0.913241692
p_ni: 0.086758308
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
DDB1
Novelty: 0.00345896
p_int: 0.889867908
p_ni: 0.110132092
Score: 0.232
Data Source: BioPlex,STRINGDB
UBR4
Family: Enzyme
Novelty: 0.03924839
p_int: 0.797159288
p_ni: 0.202840712
Data Source: BioPlex
Nearest Tclin Targets
Pathways (14)
Reactome (7)
KEGG (2)
PathwayCommons (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Regulation of TP53 Activity | ||||
Reactome | Regulation of TP53 Degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Regulation of TP53 Activity | ||||
Regulation of TP53 Degradation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 3 | 1 | 3 | 60.5 | |||||
metabolite measurement | 1 | 1 | 1 | 1.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 3 | 60.5 | |||||
metabolite measurement | 1 | 1.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin G1 | VGNC:3936 | 462243 | |||||
Macaque | cyclin G1 | 697738 | ||||||
Mouse | MGI:102890 | 12450 | ||||||
Rat | RGD:2295 | 25405 | ||||||
Dog | cyclin G1 | VGNC:38900 | 479303 | |||||
Publication Statistics
PubMed Score 123.81
PubMed score by year
PubTator Score 80.09
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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