Tbio CCNG1 Cyclin-G1

Protein Summary

Description

May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P51959
• B2R7B2
• B4DLW7
• D3DQK7
• Q15757
• Q96L32
• Cyclin-G

Gene Name

• CCNG1

Ensembl ID

• ENST00000340828
• ENSP00000344635
• ENSG00000113328
• ENST00000393929
• ENSP00000377506
• ENST00000512163
• ENSP00000424315

Symbol

• CCNG
• CYCG1
• CCNG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.99
disease perturbation	0.96
transcription factor binding site profile	0.78
PubMedID	0.74

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-g1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-g1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.81   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 278   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.81   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (115)

Explore Interacting Targets

1 – 10 of 115

• See Interactions on String-DB

CPSF4L

Tdark

Novelty:  4.27116708

p_int:  0.999991261

p_ni:  7.2e-8

p_wrong:  0.000008667

Score:  0.218

Data Source:  BioPlex,STRINGDB

PPP2R5D

Tbio

Family:  Enzyme

Novelty:  0.03990599

p_int:  0.994294237

p_ni:  0.005705762

Score:  0.388

Data Source:  BioPlex,STRINGDB

PPP2R5E

Tbio

Family:  Enzyme

Novelty:  0.05974697

p_int:  0.992336295

p_ni:  0.007663705

Score:  0.376

Data Source:  BioPlex,STRINGDB

ZZEF1

Tdark

Novelty:  0.33216648

p_int:  0.976119544

p_ni:  0.023880456

Score:  0.152

Data Source:  BioPlex,STRINGDB

CUL4A

Tchem

Novelty:  0.00917788

p_int:  0.952972969

p_ni:  0.047027031

Score:  0.322

Data Source:  BioPlex,STRINGDB

CUL4B

Tbio

Novelty:  0.0133075

p_int:  0.942702166

p_ni:  0.057297834

Score:  0.305

Data Source:  BioPlex,STRINGDB

PPP2R5C

Tbio

Family:  Enzyme

Novelty:  0.03336609

p_int:  0.913241692

p_ni:  0.086758308

Score:  0.948

Data Source:  BioPlex,Reactome,STRINGDB

DDB1

Tbio

Novelty:  0.00345896

p_int:  0.889867908

p_ni:  0.110132092

Score:  0.232

Data Source:  BioPlex,STRINGDB

UBR4

Tbio

Family:  Enzyme

Novelty:  0.03924839

p_int:  0.797159288

p_ni:  0.202840712

Data Source:  BioPlex

TP53

Tchem

Family:  TF

Novelty:  0.00001907

Score:  0.994

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (7)

KEGG (2)

PathwayCommons (3)

WikiPathways (2)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Regulation of TP53 Activity	160 targets	R-HSA-5633007
Reactome	Regulation of TP53 Degradation	37 targets	R-HSA-6804757

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Regulation of TP53 Activity	160 targets	R-HSA-5633007
Regulation of TP53 Degradation	37 targets	R-HSA-6804757

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (2)

Components (4)

Processes (7)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein kinase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3	1	3		60.5
metabolite measurement	EFO_0004725	1	1	1		1.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3		60.5
metabolite measurement	EFO_0004725	1		1.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cyclin
Mitosis
Nucleus
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
metabolite measurement
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
digestive/alimentary phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cyclin G1	VGNC:3936	462243
Macaque	cyclin G1		697738
Mouse	cyclin G1	MGI:102890	12450
Rat	cyclin G1	RGD:2295	25405
Dog	cyclin G1	VGNC:38900	479303

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin G1
Macaque	cyclin G1
Mouse	cyclin G1
Rat	cyclin G1
Dog	cyclin G1

Publication Statistics

PubMed Score 123.81

PubMed score by year

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PubTator Score 80.09

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (25)

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PMID	Year	Title