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Tbio
CCNF
Cyclin-F

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397066
  • ENSP00000380256
  • ENSG00000162063

Symbol
  • FBX1
  • FBXO1
  • FBX1
  • FBXO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
protein domain
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (454)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999996743
p_ni:  0.00000257
p_wrong:  6.87e-7
Score:  0.99
Data Source:  BioPlex,STRINGDB
CDC6
Tbio
Novelty:  0.00219371
p_int:  0.999993886
p_ni:  0.000004406
p_wrong:  0.000001707
Score:  0.864
Data Source:  BioPlex,STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.995
Data Source:  STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
Score:  0.982
Data Source:  STRINGDB
BTRC
Tbio
Novelty:  0.00293475
Score:  0.979
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.979
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.975
Data Source:  STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.967
Data Source:  STRINGDB
FBXL7
Tbio
Novelty:  0.10670779
Score:  0.967
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
55.8
mean reticulocyte volume
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
55.8
mean reticulocyte volume
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin F
VGNC:5703
453835
Macaque
cyclin F
696745
Mouse
MGI:102551
12449
Rat
RGD:67401
117524
Dog
cyclin F
VGNC:38899
610890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin F
Macaque
cyclin F
Mouse
Rat
Dog
cyclin F
Publication Statistics
PubMed Score 88.64
PubMed score by year
PubTator Score 21.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title