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Tchem
CCNE1
G1/S-specific cyclin-E1

Protein Summary
Description
Essential for the control of the cell cycle at the G1/S (start) transition. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262643
  • ENSP00000262643
  • ENSG00000105173
  • ENST00000444983
  • ENSP00000410179

Symbol
  • CCNE
  • CCNE
  • pCCNE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
virus perturbation
0.94
PubMedID
0.92
biological term
0.84
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 470.35   (req: < 5)
Gene RIFs: 225   (req: <= 3)
Antibodies: 1089   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 470.35   (req: >= 5)
Gene RIFs: 225   (req: > 3)
Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0