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Tbio
CCNDBP1
Cyclin-D1-binding protein 1

Protein Summary
Description
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300213
  • ENSP00000300213
  • ENSG00000166946
  • ENST00000565296
  • ENSP00000455419
  • ENST00000566515
  • ENSP00000456797

Symbol
  • DIP1
  • GCIP
  • HHM
  • HHM
  • DIP1
  • GCIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
virus perturbation
0.88
cell type or tissue
0.84
histone modification site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.61   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.61   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
RPLP0
Tbio
Novelty:  0.00398127
p_int:  0.999999993
p_ni:  7e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
SEC14L1
Tbio
Novelty:  0.09562071
p_int:  0.999999606
p_ni:  3.92e-7
p_wrong:  2e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
TBC1D21
Tdark
Novelty:  0.45203791
p_int:  0.999997958
p_ni:  0.000002042
Data Source:  BioPlex
MCRIP2
Tdark
Novelty:  1.50465727
p_int:  0.999994964
p_ni:  0.000002819
p_wrong:  0.000002218
Score:  0.403
Data Source:  BioPlex,STRINGDB
INO80E
Tdark
Novelty:  0.38735443
p_int:  0.999985679
p_ni:  0.000013647
p_wrong:  6.73e-7
Score:  0.738
Data Source:  BioPlex,STRINGDB
MDM4
Tchem
Novelty:  0.00321558
p_int:  0.999985667
p_ni:  0.000014333
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZNF627
Tdark
Family:  TF
Novelty:  0.34605017
p_int:  0.999976107
p_ni:  0.000020488
p_wrong:  0.000003405
Score:  0.252
Data Source:  BioPlex,STRINGDB
NFRKB
Tbio
Novelty:  0.13445983
p_int:  0.999971932
p_ni:  0.000028068
Score:  0.524
Data Source:  BioPlex,STRINGDB
TFPT
Tbio
Novelty:  0.08573384
p_int:  0.999910668
p_ni:  0.000071034
p_wrong:  0.000018297
Score:  0.775
Data Source:  BioPlex,STRINGDB
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.999897965
p_ni:  0.000102034
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
59.6
high density lipoprotein cholesterol measurement
1
1
1
53.3
apolipoprotein A 1 measurement
1
1
1
45.2
self reported educational attainment
1
1
1
26.6
household income
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
59.6
high density lipoprotein cholesterol measurement
1
53.3
apolipoprotein A 1 measurement
1
45.2
self reported educational attainment
1
26.6
household income
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin D1 binding protein 1
VGNC:10165
453373
Macaque
cyclin D1 binding protein 1
709589
Mouse
MGI:109595
17151
Rat
RGD:1304669
362201
Dog
cyclin D1 binding protein 1
VGNC:38897
607896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin D1 binding protein 1
Macaque
cyclin D1 binding protein 1
Mouse
Rat
Dog
cyclin D1 binding protein 1
Publication Statistics
PubMed Score 78.61
PubMed score by year
PubTator Score 30.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title