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Tchem
CCND3
G1/S-specific cyclin-D3

Protein Summary
Description
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the ce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372988
  • ENSP00000362079
  • ENSG00000112576
  • ENST00000372991
  • ENSP00000362082
  • ENST00000414200
  • ENSP00000397545
  • ENST00000415497
  • ENSP00000401595
  • ENST00000511642
  • ENSP00000426212
  • ENST00000616010
  • ENSP00000484424
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor perturbation
0.97
PubMedID
0.96
transcription factor binding site profile
0.93
chemical
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.61   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 756   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.61   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0