Tbio CCNC Cyclin-C

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24863
• B4DPZ1
• Q9H543

Gene Name

• CCNC

Ensembl ID

• ENST00000520429
• ENSP00000428982
• ENSG00000112237
• ENST00000523799
• ENSP00000430014
• ENST00000523985
• ENSP00000430119

Symbol

• CycC
• SRB11
• hSRB11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
transcription factor binding site profile	0.88
drug perturbation	0.87
PubMedID	0.82
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cyclin-c

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Cyclin-c

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-c

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.22   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.22   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0