Protein Summary
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs ...more
- ENST00000520429
- ENSP00000428982
- ENSG00000112237
- ENST00000523799
- ENSP00000430014
- ENST00000523985
- ENSP00000430119
- CycC
- SRB11
- hSRB11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 0.95 | ||
transcription factor binding site profile | 0.88 | ||
drug perturbation | 0.87 | ||
PubMedID | 0.82 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 171.05 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 300 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 171.05 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 300 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (163)
CDK8
Family: Kinase
Novelty: 0.00508026
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MED7
Family: Enzyme
Novelty: 0.04773947
p_int: 0.999999998
p_ni: 2e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
MED13
Family: Enzyme
Novelty: 0.02090708
p_int: 0.999999807
p_ni: 1.93e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
MED19
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999697
p_ni: 3.03e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED12L
Family: Enzyme
Novelty: 0.09658419
p_int: 0.999999634
p_ni: 3.66e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
MED24
Family: Enzyme
Novelty: 0.05466084
p_int: 0.999999108
p_ni: 8.92e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (25)
Reactome (24)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Developmental Biology | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
puberty onset measurement | 4 | 1 | 4 | 33 | |||||
age at menarche | 1 | 1 | 1 | 14 | |||||
enuresis | 1 | 1 | 0 | 1.2 | 11.5 | ||||
daytime rest measurement | 1 | 1 | 1 | 7.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
puberty onset measurement | 4 | 33 | |||||
age at menarche | 1 | 14 | |||||
enuresis | 0 | 1.2 | 11.5 | ||||
daytime rest measurement | 1 | 7.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin C | VGNC:2655 | 736585 | |||||
Macaque | cyclin C | 694465 | ||||||
Mouse | MGI:1858199 | 51813 | ||||||
Rat | RGD:70905 | 114839 | ||||||
Dog | cyclin C [Source:HGNC Symbol;Acc:HGNC:1581] | |||||||
Publication Statistics
PubMed Score 171.05
PubMed score by year
PubTator Score 62.19
PubTator score by year
Related Publications
Text Mined References (48)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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