Protein Summary
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs ...more
- ENST00000520429
- ENSP00000428982
- ENSG00000112237
- ENST00000523799
- ENSP00000430014
- ENST00000523985
- ENSP00000430119
- CycC
- SRB11
- hSRB11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.95 | ||
transcription factor binding site profile | 0.88 | ||
drug perturbation | 0.87 | ||
PubMedID | 0.82 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 171.05 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 300 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 171.05 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 300 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (163)
CDK8
Family: Kinase
Novelty: 0.00508026
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MED7
Family: Enzyme
Novelty: 0.04773947
p_int: 0.999999998
p_ni: 2e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
MED13
Family: Enzyme
Novelty: 0.02090708
p_int: 0.999999807
p_ni: 1.93e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
MED19
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999697
p_ni: 3.03e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED12L
Family: Enzyme
Novelty: 0.09658419
p_int: 0.999999634
p_ni: 3.66e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
MED24
Family: Enzyme
Novelty: 0.05466084
p_int: 0.999999108
p_ni: 8.92e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (25)
Reactome (24)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Developmental Biology | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
puberty onset measurement | 4 | 1 | 4 | 33 | |||||
age at menarche | 1 | 1 | 1 | 14 | |||||
enuresis | 1 | 1 | 0 | 1.2 | 11.5 | ||||
daytime rest measurement | 1 | 1 | 1 | 7.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
puberty onset measurement | 4 | 33 | |||||
age at menarche | 1 | 14 | |||||
enuresis | 0 | 1.2 | 11.5 | ||||
daytime rest measurement | 1 | 7.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cyclin C | VGNC:2655 | 736585 | |||||
Macaque | cyclin C | 694465 | ||||||
Mouse | MGI:1858199 | 51813 | ||||||
Rat | RGD:70905 | 114839 | ||||||
Dog | cyclin C [Source:HGNC Symbol;Acc:HGNC:1581] | |||||||
Publication Statistics
PubMed Score 171.05
PubMed score by year
PubTator Score 62.19
PubTator score by year
Related Publications
Text Mined References (48)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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