Tbio CCNB3 G2/mitotic-specific cyclin-B3

Protein Summary

Description

Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q8WWL7
• B1AQI5
• B1AQI6
• Q96SB5
• Q96SB6
• Q96SB7
• Q9NT38

Gene Name

• CCNB3

Ensembl ID

• ENST00000276014
• ENSP00000276014
• ENSG00000147082
• ENST00000348603
• ENSP00000338682
• ENST00000376038
• ENSP00000365206
• ENST00000376042
• ENSP00000365210
• ENST00000476167
• ENSP00000431645

Symbol

• CYCB3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
protein domain	0.58
tissue sample	0.58
cell line	0.52
pathway	0.48

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G2/mitotic-specific Cyclin-b3

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G2/mitotic-specific Cyclin-b3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.6   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.6   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0