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Tbio
CCNB3
G2/mitotic-specific cyclin-B3

Protein Summary
Description
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276014
  • ENSP00000276014
  • ENSG00000147082
  • ENST00000348603
  • ENSP00000338682
  • ENST00000376038
  • ENSP00000365206
  • ENST00000376042
  • ENSP00000365210
  • ENST00000476167
  • ENSP00000431645

Symbol
  • CYCB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.58
tissue sample
0.58
cell line
0.52
pathway
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.6   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.6   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
p_int:  0.999999946
p_ni:  5.4e-8
Score:  0.367
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.998
Data Source:  STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.991
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.991
Data Source:  STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
Score:  0.991
Data Source:  STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.981
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.964
Data Source:  STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.943
Data Source:  STRINGDB
NUSAP1
Tbio
Novelty:  0.01702118
Score:  0.926
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (8)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Cell cycle
KEGG
FoxO signaling pathway
KEGG
Human immunodeficiency virus 1 infection
KEGG
Cellular senescence
KEGG
Progesterone-mediated oocyte maturation
Name
Explore in Pharos
Explore in Source
Cell cycle
FoxO signaling pathway
Human immunodeficiency virus 1 infection
Cellular senescence
Progesterone-mediated oocyte maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.6
91.5
body weight
1
1
1
41.5
educational attainment
1
1
1
37.4
hematocrit
1
1
1
28.6
hemoglobin measurement
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.6
91.5
body weight
1
41.5
educational attainment
1
37.4
hematocrit
1
28.6
hemoglobin measurement
1
22.8
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2183443
209091
Rat
RGD:1564367
317389
Dog
cyclin B3
VGNC:38895
449494
Pig
cyclin B3
100515638
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cyclin B3
Pig
cyclin B3
Publication Statistics
PubMed Score 73.60
PubMed score by year
PubTator Score 22.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title