You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCL8
C-C motif chemokine 8

Protein Summary
Description
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394620
  • ENSP00000378118
  • ENSG00000108700

Symbol
  • MCP2
  • SCYA10
  • SCYA8
  • HC14
  • MCP2
  • MCP-2
  • SCYA8
  • SCYA10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
molecular function
0.86
phenotype
0.76
disease
0.7
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.39   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.39   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.976
Data Source:  STRINGDB
CCR2
Tchem
Family:  GPCR
Novelty:  0.0006525
Score:  0.962
Data Source:  STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.945
Data Source:  STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
Score:  0.938
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.903
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.896
Data Source:  STRINGDB
XCR1
Tbio
Family:  GPCR
Novelty:  0.00971657
Score:  0.87
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.846
Data Source:  STRINGDB
CCR10
Tchem
Family:  GPCR
Novelty:  0.014331
Score:  0.836
Data Source:  STRINGDB
CXCL2
Tbio
Novelty:  0.00201175
Score:  0.827
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (4)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
80.3
3
2
0
1.2
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
80.3
0
1.2
79
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 8
VGNC:9170
468209
Macaque
C-C motif chemokine ligand 8
574179
Mouse
MGI:103576
20292
Rat
RGD:1309255
287562
Dog
chemokine (C-C motif) ligand 8
448792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 8
Macaque
C-C motif chemokine ligand 8
Mouse
Rat
Dog
chemokine (C-C motif) ligand 8
Publication Statistics
PubMed Score 211.39
PubMed score by year
PubTator Score 130.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title