You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CCL5
C-C motif chemokine 5

Protein Summary
Description
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilizat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000603197
  • ENSP00000474412
  • ENSG00000271503
  • ENST00000605140
  • ENSP00000475057
  • ENST00000613606
  • ENSP00000479894
  • ENSG00000274233
  • ENST00000618639
  • ENSP00000484921

Symbol
  • D17S136E
  • SCYA5
  • SISd
  • eoCP
  • SCYA5
  • RANTES
  • TCP228
  • D17S136E
  • SIS-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3030.3   (req: < 5)
Gene RIFs: 462   (req: <= 3)
Antibodies: 882   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3030.3   (req: >= 5)
Gene RIFs: 462   (req: > 3)
Antibodies: 882   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 79
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (535)
C4A
Tbio
Novelty:  0.00062793
p_int:  0.996994267
p_ni:  0.002485949
p_wrong:  0.000519783
Score:  0.357
Data Source:  BioPlex,STRINGDB
NTMT1
Tchem
Family:  Enzyme
Novelty:  0.06322967
p_int:  0.990960426
p_ni:  0.002723153
p_wrong:  0.006316421
Score:  0.209
Data Source:  BioPlex,STRINGDB
SPATA20
Tdark
Novelty:  0.34126403
p_int:  0.974397089
p_ni:  0.025602911
Score:  0.169
Data Source:  BioPlex,STRINGDB
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
p_int:  0.951429026
p_ni:  0.048570782
p_wrong:  1.92e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.862306437
p_ni:  0.137681568
p_wrong:  0.000011995
Data Source:  BioPlex
SPRYD4
Tdark
Novelty:  0.44404169
p_int:  0.847877884
p_ni:  0.152100524
p_wrong:  0.000021592
Score:  0.252
Data Source:  BioPlex,STRINGDB
GPD1L
Tbio
Family:  Enzyme
Novelty:  0.0169606
p_int:  0.836233293
p_ni:  0.163766707
Score:  0.188
Data Source:  BioPlex,STRINGDB
S100A13
Tbio
Novelty:  0.0283577
p_int:  0.770910481
p_ni:  0.229083869
p_wrong:  0.00000565
Score:  0.235
Data Source:  BioPlex,STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.999
Data Source:  Reactome,STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (94)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (82)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
2
3
68.4
reticulocyte count
3
2
3
68.4
reticulocyte measurement
2
1
2
50.6
reticulocyte measurement
2
1
2
50.6
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
68.4
reticulocyte count
3
68.4
reticulocyte measurement
2
50.6
reticulocyte measurement
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 3030.30
PubMed score by year
PubTator Score 1737.10
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title