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Tbio
CCL4
C-C motif chemokine 4

Protein Summary
Description
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615863
  • ENSP00000482259
  • ENSG00000275302
  • ENST00000617322
  • ENSP00000480345
  • ENSG00000275824
  • ENST00000621600
  • ENSP00000478708
  • ENSG00000277943

Symbol
  • LAG1
  • MIP1B
  • SCYA4
  • ACT2
  • G-26
  • HC21
  • LAG1
  • LAG-1
  • MIP1B
  • SCYA2
  • SCYA4
  • MIP1B1
  • AT744.1
  • MIP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
chemical
0.94
gene perturbation
0.9
biological term
0.79
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1519.3   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 551   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1519.3   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0