Tbio CCL3L1 C-C motif chemokine 3-like 1

Protein Summary

Description

Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• P16619
• A6NGK6
• B2RUX4
• Q3B7A8
• Q53YA5
• Q96I68

Gene Name

• CCL3L1

Ensembl ID

• ENST00000612067
• ENSP00000484704
• ENSG00000277796
• ENST00000615140
• ENSP00000480051
• ENSG00000277768
• ENST00000619989
• ENSP00000480558
• ENSG00000276085
• ENST00000621940
• ENSP00000482487
• ENSG00000277336

Symbol

• D17S1718
• G0S19-2
• SCYA3L1
• LD78
• 464.2
• SCYA3L
• G0S19-2
• SCYA3L1
• D17S1718
• LD78BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.61
tissue	0.59
PubMedID	0.53
phenotype	0.5
tissue sample	0.49

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 3-like 1

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 3-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.68   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.68   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0