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Tbio
CCL3L1
C-C motif chemokine 3-like 1

Protein Summary
Description
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612067
  • ENSP00000484704
  • ENSG00000277796
  • ENST00000615140
  • ENSP00000480051
  • ENSG00000277768
  • ENST00000619989
  • ENSP00000480558
  • ENSG00000276085
  • ENST00000621940
  • ENSP00000482487
  • ENSG00000277336

Symbol
  • D17S1718
  • G0S19-2
  • SCYA3L1
  • LD78
  • 464.2
  • SCYA3L
  • G0S19-2
  • SCYA3L1
  • D17S1718
  • LD78BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.61
tissue
0.59
PubMedID
0.53
phenotype
0.5
tissue sample
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
TLN2
Tbio
Novelty:  0.0284423
p_int:  0.999999777
p_ni:  2.23e-7
Data Source:  BioPlex
CMC1
Tdark
Novelty:  5.14727585
p_int:  0.999818396
p_ni:  0.000123675
p_wrong:  0.000057929
Data Source:  BioPlex
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.999806768
p_ni:  0.000193219
p_wrong:  1.3e-8
Data Source:  BioPlex
QSOX1
Tbio
Family:  Enzyme
Novelty:  0.02152583
p_int:  0.999621986
p_ni:  0.000378014
Data Source:  BioPlex
EMILIN2
Tbio
Novelty:  0.2816786
p_int:  0.999167691
p_ni:  0.000831168
p_wrong:  0.000001141
Data Source:  BioPlex
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
p_int:  0.998736274
p_ni:  0.001263726
Score:  0.224
Data Source:  BioPlex,STRINGDB
TLN1
Tbio
Novelty:  0.00803981
p_int:  0.998046048
p_ni:  0.001953952
Data Source:  BioPlex
AMZ2
Tdark
Family:  Enzyme
Novelty:  0.27424719
p_int:  0.995779269
p_ni:  0.004220731
Data Source:  BioPlex
H6PD
Tbio
Novelty:  0.00366637
p_int:  0.995602035
p_ni:  0.004397519
p_wrong:  4.46e-7
Data Source:  BioPlex
SEMA3C
Tbio
Novelty:  0.00828813
p_int:  0.995399459
p_ni:  0.004589865
p_wrong:  0.000010675
Data Source:  BioPlex
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (13)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-C motif chemokine 3 measurement
1
2
2
89
C-C motif chemokine 3 measurement
1
2
2
89
C-C motif chemokine 3 measurement
1
2
2
89
macrophage inflammatory protein 1b measurement
1
2
2
87.5
macrophage inflammatory protein 1b measurement
1
2
2
87.5
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-C motif chemokine 3 measurement
2
89
C-C motif chemokine 3 measurement
2
89
C-C motif chemokine 3 measurement
2
89
macrophage inflammatory protein 1b measurement
2
87.5
macrophage inflammatory protein 1b measurement
2
87.5
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 92.51
PubMed score by year
PubTator Score 10.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title