CCL3
C-C motif chemokine 3
Protein Summary
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
- ENST00000613396
- ENSP00000480753
- ENSG00000278567
- ENST00000613922
- ENSP00000477908
- ENSG00000277632
- ENST00000616221
- ENSP00000483712
- ENSG00000274221
- G0S19-1
- MIP1A
- SCYA3
- MIP1A
- SCYA3
- G0S19-1
- LD78ALPHA
- MIP-1-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 0.99 | ||
molecular function | 0.93 | ||
biological term | 0.91 | ||
disease | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2162.43 (req: < 5)
Gene RIFs: 164 (req: <= 3)
Antibodies: 878 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2162.43 (req: >= 5)
Gene RIFs: 164 (req: > 3)
Antibodies: 878 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 63
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0