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Tbio
CCL26
C-C motif chemokine 26

Protein Summary
Description
Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005180
  • ENSP00000005180
  • ENSG00000006606
  • ENST00000394905
  • ENSP00000378365

Symbol
  • SCYA26
  • IMAC
  • TSC-1
  • MIP-4a
  • SCYA26
  • MIP-4alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.68
phenotype
0.61
tissue
0.6
biological process
0.58
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.12   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.12   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.999967859
p_ni:  0.000032141
Data Source:  BioPlex
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.99952292
p_ni:  0.000477075
p_wrong:  5e-9
Data Source:  BioPlex
TBL1X
Tbio
Novelty:  0.00027212
p_int:  0.997940513
p_ni:  0.002056179
p_wrong:  0.000003308
Data Source:  BioPlex
THUMPD1
Tdark
Novelty:  0.19420931
p_int:  0.997825087
p_ni:  0.001989666
p_wrong:  0.000185247
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.997431863
p_ni:  0.002323621
p_wrong:  0.000244517
Data Source:  BioPlex
PASK
Tchem
Family:  Kinase
Novelty:  0.14004084
p_int:  0.991735715
p_ni:  0.008264285
Data Source:  BioPlex
TBL1XR1
Tbio
Novelty:  0.00503043
p_int:  0.985081548
p_ni:  0.014764807
p_wrong:  0.000153645
Data Source:  BioPlex
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.959593469
p_ni:  0.040388111
p_wrong:  0.00001842
Data Source:  BioPlex
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.957837624
p_ni:  0.041451605
p_wrong:  0.000710771
Data Source:  BioPlex
WDHD1
Tbio
Novelty:  0.01511313
p_int:  0.948204261
p_ni:  0.051784315
p_wrong:  0.000011424
Data Source:  BioPlex
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (226)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
8
9
99
eosinophil percentage of leukocytes
2
8
8
98.2
sum of eosinophil and basophil counts
1
4
4
94.8
eosinophil percentage of granulocytes
1
4
4
94.5
neutrophil percentage of granulocytes
1
3
3
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
9
99
eosinophil percentage of leukocytes
8
98.2
sum of eosinophil and basophil counts
4
94.8
eosinophil percentage of granulocytes
4
94.5
neutrophil percentage of granulocytes
3
90.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 26
VGNC:4302
472417
Macaque
C-C motif chemokine ligand 26
716099
Mouse
MGI:3589281
541307
Rat
RGD:1587817
685958
Dog
C-C motif chemokine ligand 26
VGNC:38888
448789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 26
Macaque
C-C motif chemokine ligand 26
Mouse
Rat
Dog
C-C motif chemokine ligand 26
Publication Statistics
PubMed Score 187.12
PubMed score by year
PubTator Score 251.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title