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Tbio
CCL21
C-C motif chemokine 21

Protein Summary
Description
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to sec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259607
  • ENSP00000259607
  • ENSG00000137077

Symbol
  • SCYA21
  • ECL
  • SLC
  • CKb9
  • TCA4
  • 6Ckine
  • SCYA21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.78
phenotype
0.56
cell line
0.54
disease
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 764.77   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 516   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 764.77   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 516   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.998542021
p_ni:  0.001457979
Score:  0.178
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.871724594
p_ni:  0.128275406
Score:  0.161
Data Source:  BioPlex,STRINGDB
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.871282403
p_ni:  0.128324751
p_wrong:  0.000392846
Score:  0.679
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.78645572
p_ni:  0.21354428
Score:  0.531
Data Source:  BioPlex,STRINGDB
CCR7
Tchem
Family:  GPCR
Novelty:  0.00084453
Score:  0.997
Data Source:  Reactome,STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.991
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.983
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.977
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.974
Data Source:  STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (15)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
1
1
80.5
7
3
2
1.1
77
testosterone measurement
1
1
1
29
body height
1
1
1
13.1
self reported educational attainment
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
80.5
2
1.1
77
testosterone measurement
1
29
body height
1
13.1
self reported educational attainment
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 21
VGNC:4651
746205
Mouse
MGI:1349183
18829
Mouse
MGI:5434896
100862177
Rat
RGD:1311996
298006
Horse
C-C motif chemokine ligand 21
100063059
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 21
Mouse
Mouse
Rat
Horse
C-C motif chemokine ligand 21
Publication Statistics
PubMed Score 764.77
PubMed score by year
PubTator Score 388.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title