You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCL20
C-C motif chemokine 20

Protein Summary
Description
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358813
  • ENSP00000351671
  • ENSG00000115009
  • ENST00000409189
  • ENSP00000386273

Symbol
  • LARC
  • MIP3A
  • SCYA20
  • CKb4
  • LARC
  • ST38
  • MIP3A
  • Exodus
  • MIP-3a
  • SCYA20
  • MIP-3-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.99
biological term
0.92
small molecule perturbation
0.81
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1533.33   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1533.33   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0