Tbio CCL20 C-C motif chemokine 20

Protein Summary

Description

Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255). This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P78556
• Q53S51
• Q99664

Gene Name

• CCL20

Ensembl ID

• ENST00000358813
• ENSP00000351671
• ENSG00000115009
• ENST00000409189
• ENSP00000386273

Symbol

• LARC
• MIP3A
• SCYA20
• CKb4
• LARC
• ST38
• MIP3A
• Exodus
• MIP-3a
• SCYA20
• MIP-3-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
virus perturbation	0.99
biological term	0.92
small molecule perturbation	0.81
biological process	0.73

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 20

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 669.18   (req: < 5)

Gene RIFs: 169   (req: <= 3)

Antibodies: 633   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 669.18   (req: >= 5)

Gene RIFs: 169   (req: > 3)

Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (379)

Explore Interacting Targets

1 – 10 of 379

• See Interactions on String-DB

CCR6

Tchem

Family:  GPCR

Novelty:  0.00257933

Score:  0.994

Data Source:  Reactome,STRINGDB

CXCL8

Tchem

Novelty:  0.00005958

Score:  0.988

Data Source:  STRINGDB

CXCL1

Tbio

Novelty:  0.00059123

Score:  0.988

Data Source:  STRINGDB

CXCL11

Tbio

Novelty:  0.00077765

Score:  0.986

Data Source:  STRINGDB

CXCL12

Tchem

Novelty:  0.00026817

Score:  0.983

Data Source:  STRINGDB

CXCL5

Tbio

Novelty:  0.00286795

Score:  0.98

Data Source:  STRINGDB

CXCL2

Tbio

Novelty:  0.00201175

Score:  0.979

Data Source:  STRINGDB

IL10

Tbio

Novelty:  0.00004352

Score:  0.979

Data Source:  STRINGDB

CCL5

Tchem

Novelty:  0.00032607

Score:  0.979

Data Source:  STRINGDB

CXCL3

Tbio

Novelty:  0.01001656

Score:  0.977

Data Source:  STRINGDB

Nearest Tclin Targets (3)

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Downstream (3)

1 – 3 of 3

CXCR4

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  3

1: Chemokine signaling pathway

2: Cytokine-cytokine receptor interaction

3: Viral protein interaction with cytokine and cytokine receptor

CCR4

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  3

1: Chemokine signaling pathway

2: Cytokine-cytokine receptor interaction

3: Viral protein interaction with cytokine and cytokine receptor

CCR5

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  3

1: Chemokine signaling pathway

2: Cytokine-cytokine receptor interaction

3: Viral protein interaction with cytokine and cytokine receptor

Pathways (51)

Reactome (12)

KEGG (6)

PathwayCommons (1)

WikiPathways (32)

Chemokine receptors bind chemokines (R-HSA-380108)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chemokine receptors bind chemokines	48 targets	R-HSA-380108
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Chemokine receptors bind chemokines	48 targets	R-HSA-380108
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (3)

Components (2)

Processes (24)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
CCR6 chemokine receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
CCR chemokine receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chemokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	EFO_0004591	2	2	0	1.1	83.4
asthma	EFO_0000270	4	3	0	1	66.8
allergy	EFO_0003785	3	2	2	1	57.7
age at onset	EFO_0004847	2	1	1	1.1	56.8
allergic rhinitis	EFO_0005854	3	3	0	1	56.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	EFO_0004591	0	1.1	83.4
asthma	EFO_0000270	0	1	66.8
allergy	EFO_0003785	2	1	57.7
age at onset	EFO_0004847	1	1.1	56.8
allergic rhinitis	EFO_0005854	0	1	56.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Antibiotic
Antimicrobial
Chemotaxis
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Inflammatory response

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
allergic rhinitis
allergy
asthma
C-C motif chemokine 20 measurement
childhood onset asthma
Eczema
inflammatory bowel disease
primary biliary cirrhosis
ulcerative colitis

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	C-C motif chemokine ligand 20	VGNC:125	459991
Macaque	C-C motif chemokine ligand 20		574182
Mouse	chemokine (C-C motif) ligand 20	MGI:1329031	20297
Rat	C-C motif chemokine ligand 20	RGD:3646	29538
Dog	C-C motif chemokine ligand 20	VGNC:38884	448790

Species	Name	OMA	EggNOG	Inparanoid
Chimp	C-C motif chemokine ligand 20
Macaque	C-C motif chemokine ligand 20
Mouse	chemokine (C-C motif) ligand 20
Rat	C-C motif chemokine ligand 20
Dog	C-C motif chemokine ligand 20

Publication Statistics

PubMed Score 669.18

PubMed score by year

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PubTator Score 499.93

PubTator score by year

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Related Publications

Text Mined References (205)

GeneRif Annotations (169)

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PMID	Year	Title