You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCL19
C-C motif chemokine 19

Protein Summary
Description
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311925
  • ENSP00000308815
  • ENSG00000172724

Symbol
  • ELC
  • MIP3B
  • SCYA19
  • ELC
  • CKb11
  • MIP3B
  • MIP-3b
  • SCYA19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.76
biological term
0.67
tissue sample
0.58
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 758.36   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 758.36   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0