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Tbio
CCL14
C-C motif chemokine 14

Protein Summary
Description
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618404
  • ENSP00000481023
  • ENSG00000276409
  • ENST00000619040
  • ENSP00000483302
  • ENSG00000277236
  • ENST00000622526
  • ENSP00000479097
  • ENST00000632700
  • ENSP00000487948

Symbol
  • NCC2
  • SCYA14
  • CC-1
  • CC-3
  • CKB1
  • MCIF
  • NCC2
  • SY14
  • HCC-1
  • HCC-3
  • NCC-2
  • SCYL2
  • SCYA14
  • HCC-1(1-74)
  • HCC-1/HCC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.71
cell line
0.63
tissue sample
0.48
disease
0.46
phenotype
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.09   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.09   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
DNLZ
Tdark
Novelty:  0.10113346
p_int:  0.999924472
p_ni:  0.000075528
Score:  0.189
Data Source:  BioPlex,STRINGDB
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.999526649
p_ni:  0.000473347
p_wrong:  4e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
AMZ2
Tbio
Family:  Enzyme
Novelty:  0.27424719
p_int:  0.999256471
p_ni:  0.000743529
Score:  0.209
Data Source:  BioPlex,STRINGDB
LRFN1
Tbio
Novelty:  0.21439206
p_int:  0.97377609
p_ni:  0.02622391
Score:  0.187
Data Source:  BioPlex,STRINGDB
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.879122482
p_ni:  0.120877518
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
Score:  0.781
Data Source:  STRINGDB
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.756
Data Source:  STRINGDB
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.744
Data Source:  STRINGDB
CCL11
Tbio
Novelty:  0.00086805
Score:  0.705
Data Source:  STRINGDB
CCL22
Tbio
Novelty:  0.00245992
Score:  0.7
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
7
6
7
96.1
blood protein measurement
7
6
7
96.1
fetal genotype effect measurement
1
2
2
95.8
fetal genotype effect measurement
1
2
2
95.8
protein measurement
1
2
2
95.8
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
7
96.1
blood protein measurement
7
96.1
fetal genotype effect measurement
2
95.8
fetal genotype effect measurement
2
95.8
protein measurement
2
95.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
C-C motif chemokine ligand 14
VGNC:52020
480603
Cow
chemokine (C-C motif) ligand 14
616723
Species
Name
OMA
EggNOG
Inparanoid
Dog
C-C motif chemokine ligand 14
Cow
chemokine (C-C motif) ligand 14
Publication Statistics
PubMed Score 116.09
PubMed score by year
PubTator Score 366.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title