Protein Summary
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
- ENST00000334681
- ENSP00000335657
- ENSG00000187094
- ENST00000396169
- ENSP00000379472
- ENST00000434608
- ENSP00000409124
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
biological process | 0.89 | ||
biological term | 0.76 | ||
chemical | 0.62 | ||
disease | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9059.35 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9059.35 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (355)
TRIM68
Family: Enzyme
Novelty: 0.11729189
p_int: 0.999948611
p_ni: 0.000051374
p_wrong: 1.5e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (25)
Reactome (7)
KEGG (3)
PathwayCommons (7)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (3)
Components (8)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 7 | 6 | 9 | 93.4 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 59.7 | |||||
gut microbiome measurement | 3 | 1 | 3 | 43.1 | |||||
educational attainment | 1 | 1 | 1 | 33.8 | |||||
physical activity measurement | 1 | 2 | 2 | 32.1 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 9 | 93.4 | |||||
comparative body size at age 10, self-reported | 1 | 59.7 | |||||
gut microbiome measurement | 3 | 43.1 | |||||
educational attainment | 1 | 33.8 | |||||
physical activity measurement | 2 | 32.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cholecystokinin | VGNC:1762 | 460290 | |||||
Macaque | cholecystokinin | 100430777 | ||||||
Mouse | MGI:88297 | 12424 | ||||||
Rat | RGD:2288 | 25298 | ||||||
Dog | cholecystokinin | VGNC:52865 | 609547 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cholecystokinin | |||||
Macaque | cholecystokinin | |||||
Mouse | ||||||
Rat | ||||||
Dog | cholecystokinin | |||||
Publication Statistics
PubMed Score 9059.35
PubMed score by year
PubTator Score 2299.87
PubTator score by year
Related Publications
Text Mined References (122)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
|---|