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Tbio
CCHCR1
Coiled-coil alpha-helical rod protein 1

Protein Summary
Description
May be a regulator of keratinocyte proliferation or differentiation. This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376266
  • ENSP00000365442
  • ENSG00000204536
  • ENST00000383341
  • ENSP00000372832
  • ENSG00000206355
  • ENST00000383527
  • ENSP00000373019
  • ENSG00000206457
  • ENST00000396268
  • ENSP00000379566
  • ENST00000400352
  • ENSP00000383205
  • ENST00000400412
  • ENSP00000383263
  • ENST00000416163
  • ENSP00000408012
  • ENSG00000234114
  • ENST00000425620
  • ENSP00000393042
  • ENST00000451521
  • ENSP00000401039

Symbol
  • C6orf18
  • HCR
  • HCR
  • SBP
  • pg8
  • C6orf18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
disease perturbation
0.74
phenotype
0.73
virus
0.66
cellular component
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.36   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.36   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.99999944
p_ni:  5.6e-7
Data Source:  BioPlex
IQCC
Tdark
Novelty:  1.83536118
p_int:  0.999998923
p_ni:  0.000001077
Score:  0.403
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999998049
p_ni:  0.000001951
Score:  0.199
Data Source:  BioPlex,STRINGDB
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.999982537
p_ni:  0.000017463
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999691929
p_ni:  0.00030791
p_wrong:  1.62e-7
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999516929
p_ni:  0.000483071
Score:  0.159
Data Source:  BioPlex,STRINGDB
MAGEA10
Tbio
Novelty:  0.05364393
p_int:  0.999286557
p_ni:  0.000713435
p_wrong:  8e-9
Data Source:  BioPlex
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.999093362
p_ni:  0.000906594
p_wrong:  4.3e-8
Data Source:  BioPlex
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.998444235
p_ni:  0.0015546
p_wrong:  0.000001165
Data Source:  BioPlex
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.99800221
p_ni:  0.001997786
p_wrong:  4e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (408)
Items per page:
1 – 5 of 408
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
10
7
3
1
98.6
type 2 diabetes mellitus
10
7
3
1
98.6
type 2 diabetes mellitus
10
7
3
1
98.6
type 2 diabetes mellitus
10
7
3
1
98.6
1
5
0
2.8
97.1
Items per page:
1 – 5 of 408
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
1
98.6
type 2 diabetes mellitus
3
1
98.6
type 2 diabetes mellitus
3
1
98.6
type 2 diabetes mellitus
3
1
98.6
0
2.8
97.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil alpha-helical rod protein 1
449588
Mouse
MGI:2385321
240084
Dog
coiled-coil alpha-helical rod protein 1
VGNC:38877
474834
Cow
coiled-coil alpha-helical rod protein 1
VGNC:26938
514215
Opossum
coiled-coil alpha-helical rod protein 1
100024679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil alpha-helical rod protein 1
Mouse
Dog
coiled-coil alpha-helical rod protein 1
Cow
coiled-coil alpha-helical rod protein 1
Opossum
coiled-coil alpha-helical rod protein 1
Publication Statistics
PubMed Score 109.36
PubMed score by year
PubTator Score 90.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title