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Tdark
CCDC85B
Coiled-coil domain-containing protein 85B

Protein Summary
Description
Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication. Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312579
  • ENSP00000311695
  • ENSG00000175602

Symbol
  • DIPA
  • DIPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
histone modification site profile
0.65
small molecule perturbation
0.64
biological process
0.61
transcription factor
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.999999812
p_ni:  1.88e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999985559
p_ni:  0.000014387
p_wrong:  5.4e-8
Score:  0.254
Data Source:  BioPlex,STRINGDB
SKA3
Tbio
Novelty:  0.05435653
p_int:  0.999870783
p_ni:  0.000129141
p_wrong:  7.6e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999806927
p_ni:  0.000193073
Score:  0.24
Data Source:  BioPlex,STRINGDB
CEBPG
Tbio
Family:  TF
Novelty:  0.07956633
p_int:  0.999662015
p_ni:  0.000152096
p_wrong:  0.000185888
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999529105
p_ni:  0.000470895
Data Source:  BioPlex
MAGEA4
Tbio
Novelty:  0.00949096
p_int:  0.999308648
p_ni:  0.000689105
p_wrong:  0.000002247
Score:  0.177
Data Source:  BioPlex,STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
p_int:  0.999184863
p_ni:  0.000807786
p_wrong:  0.000007351
Data Source:  BioPlex
CCDC136
Tbio
Novelty:  0.09279967
p_int:  0.998948943
p_ni:  0.001041412
p_wrong:  0.000009645
Score:  0.213
Data Source:  BioPlex,STRINGDB
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.998888979
p_ni:  0.001099219
p_wrong:  0.000011802
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
5
5
98.1
uric acid measurement
2
2
2
93.1
eosinophil count
4
3
4
88.1
1
1
0
1.1
86.8
sex hormone-binding globulin measurement
9
1
8
7.7
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
98.1
uric acid measurement
2
93.1
eosinophil count
4
88.1
0
1.1
86.8
sex hormone-binding globulin measurement
8
7.7
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 85B
VGNC:3165
745892
Macaque
coiled-coil domain containing 85B
715413
Mouse
MGI:2147607
240514
Dog
coiled-coil domain containing 85B
VGNC:38863
610847
Cow
coiled-coil domain containing 85B
VGNC:26924
540332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 85B
Macaque
coiled-coil domain containing 85B
Mouse
Dog
coiled-coil domain containing 85B
Cow
coiled-coil domain containing 85B
Publication Statistics
PubMed Score 87.00
PubMed score by year
PubTator Score 8.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title