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Tdark
CCDC69
Coiled-coil domain-containing protein 69

Protein Summary
Description
May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355417
  • ENSP00000347586
  • ENSG00000198624
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.54
histone modification site profile
0.53
PubMedID
0.5
small molecule perturbation
0.5
microRNA
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
RMI1
Tbio
Novelty:  0.01222442
p_int:  0.999999922
p_ni:  6.1e-8
p_wrong:  1.7e-8
Score:  0.809
Data Source:  BioPlex,STRINGDB
TOP3A
Tbio
Family:  Enzyme
Novelty:  0.0055546
p_int:  0.999997063
p_ni:  0.000002935
p_wrong:  1e-9
Score:  0.547
Data Source:  BioPlex,STRINGDB
MMADHC
Tbio
Novelty:  0.02299238
p_int:  0.999887805
p_ni:  0.000111992
p_wrong:  2.04e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
PSMG4
Tdark
Novelty:  0.05339077
p_int:  0.999690755
p_ni:  0.000309237
p_wrong:  8e-9
Data Source:  BioPlex
NUDT8
Tdark
Novelty:  0.76306116
p_int:  0.998551712
p_ni:  0.001263031
p_wrong:  0.000185257
Score:  0.554
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.99842455
p_ni:  0.001575449
p_wrong:  1e-9
Data Source:  BioPlex
FAM192A
Tdark
Novelty:  0.46220707
p_int:  0.996665614
p_ni:  0.003334386
Score:  0.223
Data Source:  BioPlex,STRINGDB
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.996471755
p_ni:  0.003528245
Data Source:  BioPlex
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.991957379
p_ni:  0.008042585
p_wrong:  3.5e-8
Data Source:  BioPlex
RMI2
Tbio
Novelty:  0.02516878
p_int:  0.981769405
p_ni:  4.3e-8
p_wrong:  0.018230552
Score:  0.826
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
88.1
3
1
0
1.6
82.9
psoriasis vulgaris
2
1
0
1.8
81.9
red blood cell distribution width
2
1
2
81.7
1
1
0
1.3
79.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
88.1
0
1.6
82.9
psoriasis vulgaris
0
1.8
81.9
red blood cell distribution width
2
81.7
0
1.3
79.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 69
713304
Mouse
MGI:1196234
52570
Rat
RGD:1562251
497906
Dog
coiled-coil domain containing 69
VGNC:38852
489176
Horse
coiled-coil domain containing 69
VGNC:16175
100071558
Species
Name
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 69
Mouse
Rat
Dog
coiled-coil domain containing 69
Horse
coiled-coil domain containing 69
Publication Statistics
PubMed Score 3.30
PubMed score by year
PubTator Score 0.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title