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Tbio
CCDC68
Coiled-coil domain-containing protein 68

Protein Summary
Description
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337363
  • ENSP00000337209
  • ENSG00000166510
  • ENST00000432185
  • ENSP00000413406
  • ENST00000591504
  • ENSP00000466690

Symbol
  • SE57-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
PubMedID
0.65
kinase perturbation
0.54
histone modification site profile
0.53
tissue sample
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
FYCO1
Tbio
Novelty:  0.06181219
p_int:  0.999998581
p_ni:  0.000001419
Score:  0.161
Data Source:  BioPlex,STRINGDB
CENPF
Tbio
Novelty:  0.00676983
p_int:  0.9995806
p_ni:  0.0004194
Score:  0.31
Data Source:  BioPlex,STRINGDB
NDC80
Tbio
Novelty:  0.00331814
p_int:  0.998928736
p_ni:  0.001071264
Score:  0.173
Data Source:  BioPlex,STRINGDB
FBP1
Tchem
Family:  Enzyme
Novelty:  0.0029987
p_int:  0.996340889
p_ni:  0.003647294
p_wrong:  0.000011817
Score:  0.226
Data Source:  BioPlex,STRINGDB
NIN
Tbio
Novelty:  0.01312714
p_int:  0.994489861
p_ni:  0.004741499
p_wrong:  0.00076864
Score:  0.934
Data Source:  BioPlex,STRINGDB
PLEC
Tbio
Novelty:  0.00223244
p_int:  0.992687381
p_ni:  0.007312619
Score:  0.201
Data Source:  BioPlex,STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.973026063
p_ni:  0.026973937
Score:  0.175
Data Source:  BioPlex,STRINGDB
BTN3A2
Tbio
Novelty:  0.06889505
p_int:  0.930517151
p_ni:  0.069482694
p_wrong:  1.55e-7
Score:  0.239
Data Source:  BioPlex,STRINGDB
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.88084885
p_ni:  0.11915115
Score:  0.928
Data Source:  BioPlex,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
84
5
4
3
1
80.9
wellbeing measurement
4
2
4
71.1
depressive symptom measurement
2
2
2
69.6
neuroticism measurement
3
3
2
6.3
69.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
84
3
1
80.9
wellbeing measurement
4
71.1
depressive symptom measurement
2
69.6
neuroticism measurement
2
6.3
69.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 68
VGNC:13246
455431
Macaque
coiled-coil domain containing 68
694841
Mouse
MGI:3612676
381175
Rat
RGD:1561424
291530
Dog
coiled-coil domain containing 68
VGNC:38851
483973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 68
Macaque
coiled-coil domain containing 68
Mouse
Rat
Dog
coiled-coil domain containing 68
Publication Statistics
PubMed Score 7.85
PubMed score by year
PubTator Score 4.42
PubTator score by year
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Related Publications
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PMID
Year
Title