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Tdark
CCDC65
Dynein regulatory complex subunit 2

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744). This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266984
  • ENSP00000266984
  • ENSG00000139537
  • ENST00000320516
  • ENSP00000312706

Symbol
  • DRC2
  • DRC2
  • FAP250
  • CFAP250
  • NYD-SP28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
histone modification site profile
0.76
cell line
0.57
tissue sample
0.57
interacting protein
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.999036999
p_ni:  0.000963
Score:  0.165
Data Source:  BioPlex,STRINGDB
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.990216655
p_ni:  0.009783344
p_wrong:  1e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.980925548
p_ni:  0.019074452
Score:  0.165
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.944585138
p_ni:  0.055414862
Score:  0.501
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.922608376
p_ni:  0.077391624
Score:  0.173
Data Source:  BioPlex,STRINGDB
DRC1
Tbio
Novelty:  0.29125683
Score:  0.924
Data Source:  STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
Score:  0.897
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.886
Data Source:  STRINGDB
GAS8
Tbio
Novelty:  0.03540885
Score:  0.881
Data Source:  STRINGDB
CFAP298
Tbio
Novelty:  0.1550579
Score:  0.85
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
16
98.1
intelligence
6
4
4
6.1
92.2
cognitive function measurement
3
2
3
89
self reported educational attainment
4
2
4
6.1
88.6
bone density
2
2
5
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
16
98.1
intelligence
4
6.1
92.2
cognitive function measurement
3
89
self reported educational attainment
4
6.1
88.6
bone density
5
88
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 65
VGNC:5325
742798
Macaque
coiled-coil domain containing 65
708483
Mouse
MGI:2146001
105833
Rat
RGD:1595842
362994
Dog
coiled-coil domain containing 65
VGNC:38849
477622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 65
Macaque
coiled-coil domain containing 65
Mouse
Rat
Dog
coiled-coil domain containing 65
Publication Statistics
PubMed Score 22.74
PubMed score by year
PubTator Score 4.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title