You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCDC6
Coiled-coil domain-containing protein 6

Protein Summary
Description
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263102
  • ENSP00000263102
  • ENSG00000108091

Symbol
  • D10S170
  • TST1
  • H4
  • PTC
  • TPC
  • TST1
  • D10S170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.83
histone modification site profile
0.83
transcription factor binding site profile
0.78
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.15   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.15   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
PPP4R1
Tbio
Family:  Enzyme
Novelty:  0.10822249
p_int:  1
Score:  0.79
Data Source:  BioPlex,STRINGDB
ZNF444
Tdark
Family:  TF
Novelty:  0.21564163
p_int:  0.99999999
p_ni:  1e-8
Score:  0.524
Data Source:  BioPlex,STRINGDB
CEP55
Tbio
Novelty:  0.01328073
p_int:  0.999999201
p_ni:  7.99e-7
Data Source:  BioPlex
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.999999029
p_ni:  9.71e-7
Data Source:  BioPlex
C1S
Tchem
Novelty:  0.00043003
p_int:  0.999998208
p_ni:  0.000001792
Score:  0.752
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999996485
p_ni:  0.000003515
Data Source:  BioPlex
PPP4R2
Tbio
Family:  Enzyme
Novelty:  0.15136638
p_int:  0.999950113
p_ni:  0.000049887
Score:  0.627
Data Source:  BioPlex,STRINGDB
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.999786157
p_ni:  0.000213843
Data Source:  BioPlex
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999669422
p_ni:  0.000330578
Score:  0.519
Data Source:  BioPlex,STRINGDB
MAFF
Tbio
Family:  TF
Novelty:  0.01974936
p_int:  0.999614513
p_ni:  0.000385487
Data Source:  BioPlex
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
RAF1
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
BRAF
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  2
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
7
10
99.3
blood metabolite measurement
3
4
9
98.2
acylcarnitine measurement
1
2
3
94.6
testosterone measurement
4
2
4
93.4
serum metabolite measurement
3
3
3
80.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
10
99.3
blood metabolite measurement
9
98.2
acylcarnitine measurement
3
94.6
testosterone measurement
4
93.4
serum metabolite measurement
3
80.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 6
VGNC:1631
466080
Macaque
coiled-coil domain containing 6
699889
Mouse
MGI:1923801
76551
Rat
RGD:1587433
691155
Dog
coiled-coil domain containing 6
VGNC:38845
488993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 6
Macaque
coiled-coil domain containing 6
Mouse
Rat
Dog
coiled-coil domain containing 6
Publication Statistics
PubMed Score 138.15
PubMed score by year
PubTator Score 104.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title