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Tbio
CCDC59
Thyroid transcription factor 1-associated protein 26

Protein Summary
Description
Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256151
  • ENSP00000256151
  • ENSG00000133773

Symbol
  • BR22
  • TAP26
  • BR22
  • TAP26
  • HSPC128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
virus perturbation
0.88
histone modification site profile
0.87
interacting protein
0.76
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
TUT7
Tbio
Family:  Enzyme
Novelty:  0.06274003
p_int:  0.99999986
p_ni:  1.39e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
HAUS4
Tbio
Novelty:  0.91427982
p_int:  0.999999222
p_ni:  7.77e-7
Data Source:  BioPlex
HAUS1
Tbio
Novelty:  0.11356375
p_int:  0.999970151
p_ni:  0.000029844
p_wrong:  5e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
CENPB
Tbio
Novelty:  0.0036225
p_int:  0.989337269
p_ni:  0.010656622
p_wrong:  0.000006109
Data Source:  BioPlex
URB1
Tbio
Novelty:  0.04246076
p_int:  0.988810768
p_ni:  0.011189232
Data Source:  BioPlex
EDC3
Tbio
Novelty:  0.02077346
p_int:  0.981640842
p_ni:  0.018359158
Data Source:  BioPlex
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.975085015
p_ni:  0.024914985
Data Source:  BioPlex
COG4
Tbio
Novelty:  0.03809668
p_int:  0.974995526
p_ni:  0.025004364
p_wrong:  1.1e-7
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.97119489
p_ni:  0.02880511
Data Source:  BioPlex
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.971174552
p_ni:  0.028825448
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 59
VGNC:5320
452102
Mouse
MGI:1289302
52713
Rat
RGD:1311912
314799
Dog
coiled-coil domain containing 59
VGNC:38844
611585
Horse
coiled-coil domain containing 59
VGNC:16169
100061266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 59
Mouse
Rat
Dog
coiled-coil domain containing 59
Horse
coiled-coil domain containing 59
Publication Statistics
PubMed Score 16.73
PubMed score by year
PubTator Score 8.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title