Tbio CCDC59 Thyroid transcription factor 1-associated protein 26

Protein Summary

Description

Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.

Uniprot Accession IDs

• Q9P031
• Q9H2V5
• Q9NW62
• TTF-1-associated protein 26

Gene Name

• CCDC59

Ensembl ID

• ENST00000256151
• ENSP00000256151
• ENSG00000133773

Symbol

• BR22
• TAP26
• BR22
• TAP26
• HSPC128

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
virus perturbation	0.88
histone modification site profile	0.87
interacting protein	0.76
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.46   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0