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Tbio
CCDC36
Interactor of HORMAD1 protein 1

Protein Summary
Description
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296449
  • ENSP00000296449
  • ENSG00000173421
  • ENST00000366429
  • ENSP00000403700
  • ENST00000438782
  • ENSP00000391788
  • ENST00000452691
  • ENSP00000407837

Symbol
  • IHO1
  • CT74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.6
tissue sample
0.59
cellular component
0.52
tissue
0.49
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
KBTBD12
Tdark
Novelty:  3.42794501
Score:  0.742
Data Source:  STRINGDB
KLHDC8B
Tbio
Novelty:  0.15409379
Score:  0.741
Data Source:  STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
Score:  0.725
Data Source:  STRINGDB
TMEM204
Tdark
Novelty:  0.21947862
Score:  0.709
Data Source:  STRINGDB
KCNG3
Tclin
Family:  IC
Novelty:  0.19740057
Score:  0.709
Data Source:  STRINGDB
SPATA48
Tdark
Novelty:  0.80758623
Score:  0.703
Data Source:  STRINGDB
DECR2
Tbio
Family:  Enzyme
Novelty:  0.03928974
Score:  0.695
Data Source:  STRINGDB
SEZ6L
Tbio
Novelty:  0.08978367
Score:  0.682
Data Source:  STRINGDB
MYO18B
Tbio
Novelty:  0.0366177
Score:  0.677
Data Source:  STRINGDB
RAB11FIP3
Tbio
Novelty:  0.07915085
Score:  0.672
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
5
2
6.6
92
red blood cell distribution width
3
2
3
89.9
self reported educational attainment
3
3
5
89.4
4
5
5
1
87.1
household income
1
2
2
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
6.6
92
red blood cell distribution width
3
89.9
self reported educational attainment
5
89.4
5
1
87.1
household income
2
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 36
VGNC:1759
743480
Mouse
MGI:3612242
434438
Rat
RGD:1596869
680018
Dog
coiled-coil domain containing 36
VGNC:38836
100688973
Horse
coiled-coil domain containing 36
VGNC:16162
100062976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 36
Mouse
Rat
Dog
coiled-coil domain containing 36
Horse
coiled-coil domain containing 36
Publication Statistics
PubMed Score 6.63
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
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PMID
Year
Title